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    Dual-source computed tomography angiography in aortic stenosis: comparison with transthoracic echocardiography

    Access Status
    Fulltext not available
    Authors
    Yaakup, N.
    Phuah, H.
    Abdul Aziz, Y.
    Zainal Abidin, I.
    Sun, Zhonghua
    Ng, K.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Yaakup, N. and Phuah, H. and Abdul Aziz, Y. and Zainal Abidin, I. and Sun, Z. and Ng, K. 2014. Dual-source computed tomography angiography in aortic stenosis: comparison with transthoracic echocardiography. Journal of Medical Imaging and Health Informatics. 4 (5): pp. 749-755.
    Source Title
    Journal of Medical Imaging and Health Informatics
    DOI
    10.1166/jmihi.2014.1305
    ISSN
    2156-7026
    School
    Department of Imaging and Applied Physics
    URI
    http://hdl.handle.net/20.500.11937/45626
    Collection
    • Curtin Research Publications
    Abstract

    The diagnostic performance of dual-source computed tomography (DSCT) angiography was evaluated in this study and compared to transthoracic echocardiography (TTE), which is commonly used as the reference standard, in the assessment of aortic valve morphology, measurement of aortic valve area (AVA) and classification of aortic valve stenosis. Forty subjects were recruited, with 20 diagnosed with aortic stenosis (AS) and the remaining 20 identified with normal aortic valve. Morphological findings of the aortic valve were compared between these two modalities. Maximum AVA was measured planimetrically in mid-systole with DSCT angiography (AVACT) and compared with TTE-derived AVA (AVATTE). There was more than 90% concordance of valve morphology between DSCT angiography and TTE (sensitivity 91.7%, specificity 100%). There was excellent correlation between AVACT and AVATTE (r = 0.98, < 0.001). Bland Altman analysis showed good inter-modality agreement (95% confidence interval [CI]: -0.26 – 0.51 cm2) with slight overestimation of AVA (+ 0.13 cm2) by DSCT. Very good correlation was observed between AVACT and the mean as well as peak transvalvular pressure gradients (r² = 0.82 and 0.84 respectively). It was concluded that DSCT angiography can be used as a reliable, non-invasive and accurate imaging modality to evaluate the aortic valve morphology.

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