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dc.contributor.authorHallaj-Nezhadi, Somayeh
dc.contributor.authorDass, Crispin
dc.contributor.authorLotfipour, Farzaneh
dc.date.accessioned2017-01-30T15:23:20Z
dc.date.available2017-01-30T15:23:20Z
dc.date.created2013-07-02T20:00:21Z
dc.date.issued2013
dc.identifier.citationHallaj-Nezhadi, Somayeh and Dass, Crispin R. and Lotfipour, Farzaneh. 2013. Intraperitoneal delivery of nanoparticles for cancer gene therapy. Future Oncology 9 (1): pp. 59-68.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/45786
dc.identifier.doi10.2217/FON.12.171
dc.description.abstract

Nanoparticle-based gene delivery systems may be more efficient for administration of therapeutic genes to solid tumors and cancer metastases, owing to the numerous advantages in terms of enhanced tissue penetrability, improved cellular uptake and targeted gene delivery to the cells of interest compared with other gene delivery systems. Intraperitoneal (IP) delivery of therapeutic agents offers special merits because of the anatomical situation of peritoneum for local cancer therapy. Via the IP administration route, it is possible to target the therapeutic agents exactly to the target cells and protect healthy tissues outside the peritoneal cavity from side effects. IP delivery could be applicable for the treatment of disorders of organs in the peritoneal cavity covered with peritoneum and subperitoneal connective tissue, including cancers such as ovarian and gastric. The goal of this article is to review the current state of IP delivery of nanoparticles for cancer gene therapy.

dc.publisherFuture Medicine
dc.subjectintraperitoneal
dc.subjectgene therapy
dc.subjectplasmid
dc.subjectnanoparticle
dc.subjectgene delivery
dc.subjectCancer
dc.titleIntraperitoneal delivery of nanoparticles for cancer gene therapy
dc.typeJournal Article
dcterms.source.volume9
dcterms.source.number1
dcterms.source.startPage59
dcterms.source.endPage68
dcterms.source.issn1479-6694
dcterms.source.titleFuture Oncology
curtin.department
curtin.accessStatusFulltext not available


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