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    A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats

    189549_73113_A_Diet_Enriched_in_Docosahexanoic_Acid.pdf (614.1Kb)
    Access Status
    Open access
    Authors
    Pallebage-Gamarallage, Menuka
    Lam, Virginie
    Takechi, Ryusuke
    Galloway, Susan
    Mamo, John
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Pallebage-Gamarallage, Menuka M. and Lam, Virginie and Takechi, Ryusuke and Galloway, Susan and Mamo, John C.L. 2012. A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats. International Journal of Vascular Medicine. Article ID 647689: 8 pages.
    Source Title
    International Journal of Vascular Medicine
    DOI
    10.1155/2012/647689
    ISBN
    2090 - 2824
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/45848
    Collection
    • Curtin Research Publications
    Abstract

    Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta. In contrast, diets enriched in mono- or polyunsaturated (PUFA) oils had no detrimental effect. Rather, n3 and n6 oils generally confer protection via suppression of inflammation. This study investigated in wild-type mice if a PUFA diet enriched in docosahexanoic acid (DHA) restored blood-brain barrier integrity and attenuated parenchymal apo B abundance induced by chronic ingestion of SFA. Cerebrovascular leakage of apo B was quantitated utilising immunofluorescent staining. The plasma concentration of brain-derived S100 β was measured as a marker of cerebrovascular inflammation. In mice fed SFA for 3 months, provision thereafter of a DHA-enriched diet exacerbated parenchymal apo B retention, concomitant with a significant increase in plasma cholesterol. In contrast, provision of a low-fat diet following chronic SFA feeding had no effect on SFA-induced parenchymal apo B. The findings suggest that in a heightened state of cerebrovascular inflammation, the provision of unsaturated fatty acids may be detrimental, possibly as a consequence of a greater susceptibility for oxidation.

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