Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1

Aghafar, M. and Witt, C. and Kamarulzaman, A. and Ismail, R. and Lederman, M. and Rodriguez, B. and Senitzer, D. et al. 2012. Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1. Tissue Antigens. 79 (5): pp. 367-371.

Source Title

Tissue Antigens

DOI

10.1111/j.1399-0039.2012.01843.x

ISSN

0001-2815

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/45881

Collection

Curtin Research Publications

Abstract

Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort.