Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
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Authors
Aghafar, M.
Witt, C.
Kamarulzaman, A.
Ismail, R.
Lederman, M.
Rodriguez, B.
Senitzer, D.
Lee, S.
Price, Patricia
Date
2012Type
Journal Article
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Aghafar, M. and Witt, C. and Kamarulzaman, A. and Ismail, R. and Lederman, M. and Rodriguez, B. and Senitzer, D. et al. 2012. Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1. Tissue Antigens. 79 (5): pp. 367-371.
Source Title
Tissue Antigens
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School
School of Biomedical Sciences
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Abstract
Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort.
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