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    Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1

    Access Status
    Fulltext not available
    Authors
    Aghafar, M.
    Witt, C.
    Kamarulzaman, A.
    Ismail, R.
    Lederman, M.
    Rodriguez, B.
    Senitzer, D.
    Lee, S.
    Price, Patricia
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Aghafar, M. and Witt, C. and Kamarulzaman, A. and Ismail, R. and Lederman, M. and Rodriguez, B. and Senitzer, D. et al. 2012. Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1. Tissue Antigens. 79 (5): pp. 367-371.
    Source Title
    Tissue Antigens
    DOI
    10.1111/j.1399-0039.2012.01843.x
    ISSN
    0001-2815
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/45881
    Collection
    • Curtin Research Publications
    Abstract

    Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort.

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