Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The profile of psychiatric symptoms exacerbated by methamphetamine use

    239665.pdf (299.3Kb)
    Access Status
    Open access
    Authors
    McKetin, Rebecca
    Dawe, S.
    Burns, R.
    Hides, L.
    Kavanagh, D.
    Teesson, M.
    McD Young, R.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    McKetin, R. and Dawe, S. and Burns, R. and Hides, L. and Kavanagh, D. and Teesson, M. and McD Young, R. 2016. The profile of psychiatric symptoms exacerbated by methamphetamine use. Drug and Alcohol Dependence. 161: pp. 104-109.
    Source Title
    Drug and Alcohol Dependence
    DOI
    10.1016/j.drugalcdep.2016.01.018
    ISSN
    1879-0046
    School
    National Drug Research Institute (NDRI)
    URI
    http://hdl.handle.net/20.500.11937/45917
    Collection
    • Curtin Research Publications
    Abstract

    Background: Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to examine the profile of psychiatric symptoms that are acutely exacerbated by methamphetamine use. Methods: 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale. Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis. Results: Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ2(df1) = 3.66, p = 0.056). Conclusion: Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome.

    Related items

    Showing items related by title, author, creator and subject.

    • Correlates of transient versus persistent psychotic symptoms among dependent methamphetamine users
      McKetin, Rebecca; Gardner, J.; Baker, A.; Dawe, S.; Ali, R.; Voce, A.; Leach, L.; Lubman, D. (2016)
      © 2016 Elsevier Ireland Ltd. This study examined correlates of transient versus persistent psychotic symptoms among people dependent on methamphetamine. A longitudinal prospective cohort study of dependent methamphetamine ...
    • Clinical and demographic characteristics of people who smoke versus inject crystalline methamphetamine in Australia: Findings from a pharmacotherapy trial
      McKetin, Rebecca ; Quinn, B.; Higgs, Peter ; Berk, M.; Dean, O.M.; Turner, A.; Kelly, P.J.; Lubman, D.I.; Carter, G.; Baker, A.L.; Manning, V.; Thomas, T.; Bathish, R.; Raftery, D.; Saunders, L.; Wrobel, A.; Meehan, A.; Sinclair, B.; Reid, D.; Arunogiri, S.; Hill, H.; Cordaro, F.; Dietze, Paul (2021)
      Introduction and Aims: There has been a rapid increase in smoking crystalline methamphetamine in Australia. We compare the clinical and demographic characteristics of those who smoke versus inject the drug in a cohort of ...
    • A Systematic Review of the Symptom Profile and Course of Methamphetamine-Associated Psychosis: Substance Use and Misuse
      Voce, A.; Calabria, B.; Burns, R.; Castle, D.; McKetin, Rebecca (2019)
      Objectives: The psychiatric symptom profile of methamphetamine-associated psychosis (MAP) has varied considerably across studies of different research designs. We performed a systematic review to examine the available ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.