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    Cigarette Smoking and Pancreatic Cancer Risk: More to the Story Than Just Pack-Years

    Access Status
    Fulltext not available
    Authors
    Schulte, A.
    Pandeya, N.
    Tran, B.
    Fawcett, J.
    Fritschi, Lin
    Risch, H.
    Webb, P.
    Whiteman, D.
    Neale, R.
    Neale, R.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Schulte, A. and Pandeya, N. and Tran, B. and Fawcett, J. and Fritschi, L. and Risch, H. and Webb, P. et al. 2014. Cigarette Smoking and Pancreatic Cancer Risk: More to the Story Than Just Pack-Years. European Journal of Cancer. 50 (5): pp. 997-1003.
    Source Title
    European Journal of Cancer
    DOI
    10.1016/j.ejca.2013.12.014
    ISSN
    0959-8049
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/45944
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: Cigarette smoking is an established risk factor for pancreatic adenocarcinoma. However, few studies have thoroughly investigated the effects of independent smoking dimensions (duration, intensity, cumulative dose and time since quitting) on risk estimates. We analysed data from the Queensland Pancreatic Cancer Study (QPCS), an Australian population-based case-control study, with the aim of determining which smoking component is primarily important to pancreatic cancer risk. Methods: Our study included 705 pancreatic cancer patients and 711 controls. Logistic regression and generalised additive logistic regression (for non-linear dose effects) were used to determine odds ratios (ORs) and 95% confidence intervals (CIs). Results: Compared to never-smokers, current smokers had an increased risk of pancreatic cancer (OR = 3.4; 95% CI 2.4–5.0) after adjustment for age, sex, education, alcohol intake and birth country. Of the various smoking dimensions, smoking duration and time since quitting had a greater effect on OR estimates (OR 1.3; 95% CI 1.1–1.4 and OR 0.8; 95% CI 0.7–0.8) than smoking intensity (OR 1.1; 95% CI 0.9–1.2), once ever-smoking was accounted for. Conclusions: This study confirms the association between cigarette smoking and pancreatic adenocarcinoma, and provides evidence to suggest that smoking pattern, in addition to dose effect, may affect disease risk.

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