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dc.contributor.authorAffandi, J.
dc.contributor.authorHendry, S.
dc.contributor.authorWaterer, G.
dc.contributor.authorThomson, R.
dc.contributor.authorWallace, H.
dc.contributor.authorBurrows, S.
dc.contributor.authorPrice, Patricia
dc.identifier.citationAffandi, J. and Hendry, S. and Waterer, G. and Thomson, R. and Wallace, H. and Burrows, S. and Price, P. 2013. Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease. Human Immunology. 74 (10): pp. 1382-1385.

The incidence of pulmonary non-tuberculous mycobacteria (NTM) disease in otherwise healthy adults is increasing as the population ages. The organisms are ubiquitous so susceptibility probably reflects a deficiency in a protective immune response. Here we investigate if singlenucleotide polymorphisms (SNP) affecting cytokines, chemokines and their receptors associate with pulmonary NTM disease. Samples from NTM patients (n=79) and healthy controls (n=188) were genotyped using TaqMan probes. Of the 16 SNPs assessed, IL28B-rs8099917*TG (rs8099917; P=0.01, OR=2.2), TNFA-1031*CC (rs1799964; p=0.02, OR=0.48) and IL10-1082*AA (rs1800896; P=0.001, OR=0.33) were significantly associated with NTM disease. IL28B-rs8099917 and IL10-1082 have been associated with perturbations of the Th1/Th2 balance, whilst TNFA-1031*CC associates with sensory neuropathy in HIV patients. IL10-1082 warrants further investigation because we observed high production of IL-10 in blood mononuclear cells from NTM patients. © 2013 American Society for Histocompatibility and Immunogenetics.

dc.titleSearching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease
dc.typeJournal Article
dcterms.source.titleHuman Immunology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available

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