Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease
dc.contributor.author | Affandi, J. | |
dc.contributor.author | Hendry, S. | |
dc.contributor.author | Waterer, G. | |
dc.contributor.author | Thomson, R. | |
dc.contributor.author | Wallace, H. | |
dc.contributor.author | Burrows, S. | |
dc.contributor.author | Price, Patricia | |
dc.date.accessioned | 2017-01-30T15:24:23Z | |
dc.date.available | 2017-01-30T15:24:23Z | |
dc.date.created | 2015-10-29T04:10:06Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Affandi, J. and Hendry, S. and Waterer, G. and Thomson, R. and Wallace, H. and Burrows, S. and Price, P. 2013. Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease. Human Immunology. 74 (10): pp. 1382-1385. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/45949 | |
dc.identifier.doi | 10.1016/j.humimm.2013.06.019 | |
dc.description.abstract |
The incidence of pulmonary non-tuberculous mycobacteria (NTM) disease in otherwise healthy adults is increasing as the population ages. The organisms are ubiquitous so susceptibility probably reflects a deficiency in a protective immune response. Here we investigate if singlenucleotide polymorphisms (SNP) affecting cytokines, chemokines and their receptors associate with pulmonary NTM disease. Samples from NTM patients (n=79) and healthy controls (n=188) were genotyped using TaqMan probes. Of the 16 SNPs assessed, IL28B-rs8099917*TG (rs8099917; P=0.01, OR=2.2), TNFA-1031*CC (rs1799964; p=0.02, OR=0.48) and IL10-1082*AA (rs1800896; P=0.001, OR=0.33) were significantly associated with NTM disease. IL28B-rs8099917 and IL10-1082 have been associated with perturbations of the Th1/Th2 balance, whilst TNFA-1031*CC associates with sensory neuropathy in HIV patients. IL10-1082 warrants further investigation because we observed high production of IL-10 in blood mononuclear cells from NTM patients. © 2013 American Society for Histocompatibility and Immunogenetics. | |
dc.title | Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease | |
dc.type | Journal Article | |
dcterms.source.volume | 74 | |
dcterms.source.number | 10 | |
dcterms.source.startPage | 1382 | |
dcterms.source.endPage | 1385 | |
dcterms.source.issn | 0198-8859 | |
dcterms.source.title | Human Immunology | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Fulltext not available |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |