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dc.contributor.authorHarrington, C.
dc.contributor.authorReen, F.
dc.contributor.authorMooij, M.
dc.contributor.authorStewart, F.
dc.contributor.authorChabot, J.
dc.contributor.authorGuerra, A.
dc.contributor.authorGlockner, F.
dc.contributor.authorNielsen, K.
dc.contributor.authorGram, L.
dc.contributor.authorDobson, A.
dc.contributor.authorAdams, C.
dc.contributor.authorO'Gara, Fergal
dc.date.accessioned2017-01-30T15:24:40Z
dc.date.available2017-01-30T15:24:40Z
dc.date.created2015-03-05T02:33:28Z
dc.date.issued2014
dc.identifier.citationHarrington, C. and Reen, F. and Mooij, M. and Stewart, F. and Chabot, J. and Guerra, A. and Glockner, F. et al. 2014. Characterisation of Non-Autoinducing Tropodithietic Acid (TDA) Production from Marine Sponge Pseudovibrio Species. Marine Drugs. 12 (12): pp. 5960-5978.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/46013
dc.identifier.doi10.3390/md12125960
dc.description.abstract

The search for new antimicrobial compounds has gained added momentum in recent years, paralleled by the exponential rise in resistance to most known classes of current antibiotics. While modifications of existing drugs have brought some limited clinical success, there remains a critical need for new classes of antimicrobial compound to which key clinical pathogens will be naive. This has provided the context and impetus to marine biodiscovery programmes that seek to isolate and characterize new activities from the aquatic ecosystem. One new antibiotic to emerge from these initiatives is the antibacterial compound tropodithietic acid (TDA). The aim of this study was to provide insight into the bioactivity of and the factors governing the production of TDA in marine Pseudovibrio isolates from a collection of marine sponges. The TDA produced by these Pseudovibrio isolates exhibited potent antimicrobial activity against a broad spectrum of clinical pathogens, while TDA tolerance was frequent in non-TDA producing marine isolates. Comparative genomics analysis suggested a high degree of conservation among the tda biosynthetic clusters while expression studies revealed coordinated regulation of TDA synthesis upon transition from log to stationary phase growth, which was not induced by TDA itself or by the presence of the C10-acyl homoserine lactone quorum sensing signal molecule.

dc.publisherM D P I AG
dc.subjectmarine
dc.subjectclinical
dc.subjectPseudovibrio
dc.subjectTDA
dc.subjectantimicrobial
dc.titleCharacterisation of Non-Autoinducing Tropodithietic Acid (TDA) Production from Marine Sponge Pseudovibrio Species
dc.typeJournal Article
dcterms.source.volume12
dcterms.source.number12
dcterms.source.startPage5960
dcterms.source.endPage5978
dcterms.source.issn1660-3397
dcterms.source.titleMarine Drugs
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


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