4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
| dc.contributor.author | Lim, Felicia Phei Lin | |
| dc.contributor.author | Dolzhenko, Anton | |
| dc.date.accessioned | 2017-01-30T15:26:04Z | |
| dc.date.available | 2017-01-30T15:26:04Z | |
| dc.date.created | 2014-11-10T20:00:27Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | Lim, F.P.L. and Dolzhenko, A. 2014. 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity. Tetrahedron Letters. 55 (49): pp. 6684-6688. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/46256 | |
| dc.identifier.doi | 10.1016/j.tetlet.2014.10.057 | |
| dc.description.abstract |
The trichloromethyl moiety was successfully employed as a leaving group in nucleophilic substitutions with various amines for the synthesis of 4-amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines. The key precursor for this reaction, 4-trichloromethylpyrazolo[1,5-a][1,3,5]triazin-2-amine, was prepared via the solvent-dependent condensation of 5-guanidino-3-phenylpyrazole with trichloroacetonitrile. In a broad biological activity screening, some of the prepared compounds were identified as CGRP receptor antagonists. | |
| dc.publisher | Pergamon | |
| dc.subject | Trichloroacetonitrile | |
| dc.subject | Aminolysis | |
| dc.subject | Triazine | |
| dc.subject | Pyrazole | |
| dc.subject | Purine analogue | |
| dc.title | 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity | |
| dc.type | Journal Article | |
| dcterms.source.volume | 55 | |
| dcterms.source.number | 49 | |
| dcterms.source.startPage | 6684 | |
| dcterms.source.endPage | 6688 | |
| dcterms.source.issn | 0040-4039 | |
| dcterms.source.title | Tetrahedron Letters | |
| curtin.department | School of Pharmacy | |
| curtin.accessStatus | Fulltext not available |