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dc.contributor.authorDolzhenko, Anton
dc.contributor.authorPastorin, G.
dc.contributor.authorDolzhenko, A.
dc.contributor.authorChui, W.
dc.date.accessioned2017-01-30T15:27:06Z
dc.date.available2017-01-30T15:27:06Z
dc.date.created2011-08-18T20:01:08Z
dc.date.issued2009
dc.identifier.citationDolzhenko, Anton and Pastorin, Giorgia and Dolzhenko, Anna and Chui, Wai. 2009. An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles. Tetrahedron Letters. 50 (18): pp. 2124-2128.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/46409
dc.identifier.doi10.1016/j.tetlet.2009.02.172
dc.description.abstract

A catalyst-free highly efficient synthesis of 3(5)-amino-5(3)-(het)aryl-1,2,4-triazoles in aqueous mediumwas performed using conventional heating and microwave irradiation. The tautomerism in the productswas investigated using NMR spectroscopy and X-ray crystallography. The effects of the substitution, temperature, solvents, and concentration on the tautomerism were studied. The triazoles were found to exist in 1H-forms, the 4H-form was not observed either in solid state or in solution. In general, 5-amino-1,2,4-triazoles were electronically preferred in the tautomeric equilibrium, but some exceptions from theestablished relationship were also identified.

dc.publisherElsevier Science Limted
dc.titleAn aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles
dc.typeJournal Article
dcterms.source.volume50
dcterms.source.number18
dcterms.source.startPage2124
dcterms.source.endPage2128
dcterms.source.issn0040-4039
dcterms.source.titleTetrahedron Letters
curtin.note

NOTICE: This is the author's version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters, 50, 18, 2009. DOI: 10.1016/j.tetlet.2009.02.172

curtin.departmentSchool of Pharmacy
curtin.accessStatusOpen access


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