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    Deploying aptameric sensing technology for rapid pandemic monitoring

    234677_234677.pdf (638.6Kb)
    Access Status
    Open access
    Authors
    Acquah, Caleb
    Danquah, Michael
    Agyei, D.
    Moy, Charles
    Sidhu, Amandeep
    Ongkudon, C.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Acquah, C. and Danquah, M. and Agyei, D. and Moy, C. and Sidhu, A. and Ongkudon, C. 2016. Deploying aptameric sensing technology for rapid pandemic monitoring. Critical Reviews in Biotechnology. 36 (6): pp. 1010-1022.
    Source Title
    Critical Reviews in Biotechnology
    DOI
    10.3109/07388551.2015.1083940
    ISSN
    0738-8551
    School
    Curtin Sarawak
    Remarks

    This is an Author's Original Manuscript of an article published by Taylor & Francis in Critical Reviews in Biotechnology on 18/9/2015, available online at <a href="http://www.tandfonline.com/10.3109/07388551.2015.1083940">http://www.tandfonline.com/10.3109/07388551.2015.1083940</a>

    URI
    http://hdl.handle.net/20.500.11937/4644
    Collection
    • Curtin Research Publications
    Abstract

    The genome of virulent strains may possess the ability to mutate by means of antigenic shift and/or antigenic drift as well as being resistant to antibiotics with time. The outbreak and spread of these virulent diseases including avian influenza (H1N1), severe acute respiratory syndrome (SARS-Corona virus), cholera (Vibrio cholera), tuberculosis (Mycobacterium tuberculosis), Ebola hemorrhagic fever (Ebola Virus) and AIDS (HIV-1) necessitate urgent attention to develop diagnostic protocols and assays for rapid detection and screening. Rapid and accurate detection of first cases with certainty will contribute significantly in preventing disease transmission and escalation to pandemic levels. As a result, there is a need to develop technologies that can meet the heavy demand of an all-embedded, inexpensive, specific and fast biosensing for the detection and screening of pathogens in active or latent forms to offer quick diagnosis and early treatments in order to avoid disease aggravation and unnecessary late treatment costs. Nucleic acid aptamers are short, single-stranded RNA or DNA sequences that can selectively bind to specific cellular and biomolecular targets. Aptamers, as new-age bioaffinity probes, have the necessary biophysical characteristics for improved pathogen detection. This article seeks to review global pandemic situations in relation to advances in pathogen detection systems. It particularly discusses aptameric biosensing and establishes application opportunities for effective pandemic monitoring. Insights into the application of continuous polymeric supports as the synthetic base for aptamer coupling to provide the needed convective mass transport for rapid screening is also presented.

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