Deploying aptameric sensing technology for rapid pandemic monitoring
MetadataShow full item record
The genome of virulent strains may possess the ability to mutate by means of antigenic shift and/or antigenic drift as well as being resistant to antibiotics with time. The outbreak and spread of these virulent diseases including avian influenza (H1N1), severe acute respiratory syndrome (SARS-Corona virus), cholera (Vibrio cholera), tuberculosis (Mycobacterium tuberculosis), Ebola hemorrhagic fever (Ebola Virus) and AIDS (HIV-1) necessitate urgent attention to develop diagnostic protocols and assays for rapid detection and screening. Rapid and accurate detection of first cases with certainty will contribute significantly in preventing disease transmission and escalation to pandemic levels. As a result, there is a need to develop technologies that can meet the heavy demand of an all-embedded, inexpensive, specific and fast biosensing for the detection and screening of pathogens in active or latent forms to offer quick diagnosis and early treatments in order to avoid disease aggravation and unnecessary late treatment costs. Nucleic acid aptamers are short, single-stranded RNA or DNA sequences that can selectively bind to specific cellular and biomolecular targets. Aptamers, as new-age bioaffinity probes, have the necessary biophysical characteristics for improved pathogen detection. This article seeks to review global pandemic situations in relation to advances in pathogen detection systems. It particularly discusses aptameric biosensing and establishes application opportunities for effective pandemic monitoring. Insights into the application of continuous polymeric supports as the synthetic base for aptamer coupling to provide the needed convective mass transport for rapid screening is also presented.
This is an Author's Original Manuscript of an article published by Taylor & Francis in Critical Reviews in Biotechnology on 18/9/2015, available online at <a href="http://www.tandfonline.com/10.3109/07388551.2015.1083940">http://www.tandfonline.com/10.3109/07388551.2015.1083940</a>
Showing items related by title, author, creator and subject.
Community-Acquired Pneumonia Due to Pandemic A(H1N1)2009 Influenzavirus and Methicillin Resistant Staphylococcus aureus Co-InfectionMurray, R.; Robinson, J.; White, J.; Hughes, F.; Coombs, Geoffrey; Pearson, J.; Tan, H.; Chidlow, G.; Williams, S.; Christiansen, Keryn; Smith, D. (2010)Background: Bacterial pneumonia is a well described complication of influenza. In recent years, community-onset methicillin-resistant Staphylococcus aureus (cMRSA) infection has emerged as a contributor to morbidity and ...
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemicHolden, M.; Hsu, L.; Kurt, K.; Weinert, L.; Mather, A.; Harris, S.; Strommenger, B.; Layer, F.; Witte, W.; de Lencastre, H.; Skov, R.; Westh, H.; Zemlickova, H.; Coombs, Geoffrey; Kearns, A.; Hill, R.; Edgeworth, J.; Gould, I.; Gant, V.; Cooke, J.; Edwards, G.; McAdam, P.; Templeton, K.; McCann, A.; Zhou, Z.; Castillo-Ramirez, S.; Feil, E.; Hudson, L.; Enright, M.; Balloux, F.; Aanensen, D.; Spratt, B.; Fitzgerald, J.; Parkhill, J.; Achtman, M.; Bentley, S.; Nubel, U. (2013)The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drugresistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally ...
Selvey, Linda; Antão, Catarina; Hall, R. (2015)In response to the severe acute respiratory syndrome (SARS) pandemic of 2003 and the influenza pandemic of 2009, many countries instituted border measures as a means of stopping or slowing the spread of disease. ...