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    Higher ß-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers

    240725_240725.pdf (382.8Kb)
    Access Status
    Open access
    Authors
    Keane, Kevin
    Mustafa, K.
    Hinchliffe, P.
    Conceicao, J.
    Yovich, John
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Keane, K. and Mustafa, K. and Hinchliffe, P. and Conceicao, J. and Yovich, J. 2015. Higher E-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers. Reproductive BioMedicine Online. 33 (2): pp.149-160.
    Source Title
    Reproductive BioMedicine Online
    DOI
    10.1016/j.rbmo.2016.04.014
    ISSN
    1472-6483
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/46460
    Collection
    • Curtin Research Publications
    Abstract

    To examine the effect of cryopreservation on developmental potential of human embryos, this study compared quantitative β-HCG concentrations at pregnancy test after IVF-fresh embryo transfer (IVF-ET) with those arising after frozen embryo transfer (FET). It also tracked outcomes of singleton pregnancies resulting from single-embryo transfers that resulted in singleton live births (n = 869; with 417 derived from IVF-ET and 452 from FET). The initial serum β-HCG concentration indicating successful implantation was measured along with the birthweight of the ensuing infants. With testing at equivalent luteal phase lengths, the median pregnancy test β-HCG was significantly higher following FET compared with fresh IVF-ET (844.5 IU/l versus 369 IU/l; P < 0.001). Despite no significant difference in the average period of gestation (38 weeks 5 days for both groups), the mean birthweight of infants born following FET was significantly heavier by 161 g (3370 g versus 3209 g; P < 0.001). Furthermore, more infants exceeded 4000 g (P < 0.001) for FET although there was no significant difference for the macrosomic category (≥4500 g). We concluded that FET programme embryos lead to infants with equivalent (if not better) developmental potential compared with IVF-ET, demonstrated by higher pregnancy β-HCG concentrations and ensuing birthweights.

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