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    The fitness for the Ageing Brain Study II (FABS II): Protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease

    Access Status
    Open access via publisher
    Authors
    Cyarto, E.
    Cox, K.
    Almeida, O.
    Flicker, L.
    Ames, D.
    Byrne, G.
    Hill, Keith
    Beer, C.
    LoGiudice, D.
    Appadurai, K.
    Irish, M.
    Renehan, E.
    Lautenschlager, N.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Cyarto, E. and Cox, K. and Almeida, O. and Flicker, L. and Ames, D. and Byrne, G. and Hill, K. et al. 2010. The fitness for the Ageing Brain Study II (FABS II): Protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease. Trials. 11.
    Source Title
    Trials
    DOI
    10.1186/1745-6215-11-120
    ISSN
    1745-6215
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/47254
    Collection
    • Curtin Research Publications
    Abstract

    Background: Observational studies have documented a potential protective effect of physical exercise in older adults who are at risk for developing Alzheimer's disease. The Fitness for the Ageing Brain II (FABS II) study is a multicentre randomized controlled clinical trial (RCT) aiming to determine whether physical activity reduces the rate of cognitive decline among individuals with Alzheimer's disease. This paper describes the background, objectives of the study, and an overview of the protocol including design, organization and data collection methods.Methods/Design: The study will recruit 230 community-dwelling participants diagnosed with Alzheimer's disease. Participants will be randomly allocated to two treatment groups: usual care group or 24-week home-based program consisting of 150 minutes per week of tailored moderate physical activity. The primary outcome measure of the study is cognitive decline as measured by the change from baseline in the total score on the Alzheimer's disease Assessment Scale-Cognitive section. Secondary outcomes of interest include behavioral and psychological symptoms, quality of life, functional level, carer burden and physical function (strength, balance, endurance, physical activity). Primary endpoints will be measured at six and twelve months following the baseline assessment.Discussion: This RCT will contribute evidence regarding the potential benefits of a systematic program of physical activity as an affordable and safe intervention for people with Alzheimer's disease. Further, if successful, physical activity in combination with usual care has the potential to alleviate the symptoms of Alzheimer's disease and improve its management and the quality of life of patients and their carers. © 2010 Cyarto et al; licensee BioMed Central Ltd.

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