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    Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients

    Access Status
    Fulltext not available
    Authors
    Chew, C.
    Cherry, C.
    Imran, D.
    Yunihastuti, E.
    Kamarulzaman, A.
    Varna, S.
    Ismail, R.
    Phipps, M.
    Aghafar, Z.
    Gut, I.
    Price, Patricia
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Chew, C. and Cherry, C. and Imran, D. and Yunihastuti, E. and Kamarulzaman, A. and Varna, S. and Ismail, R. et al. 2011. Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients. Tissue Antigens. 77 (2): pp. 126-130.
    Source Title
    Tissue Antigens
    DOI
    10.1111/j.1399-0039.2010.01570.x
    ISSN
    0001-2815
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/47345
    Collection
    • Curtin Research Publications
    Abstract

    In human immunodeficiency virus (HIV) patients, neuropathy is a common adverse side effect to some antiretroviral treatments, particularly stavudine. As stavudine is cheap, it is widely used in Asia and Africa. We showed that increasing age and height moderately predict the development of neuropathy. This was improved by the inclusion of tumour necrosis factor (TNF)-1031 (rs1799964). To investigate this association, Malay (n = 64), Chinese (n = 74) and Caucasian patients (n = 37) exposed to stavudine were screened for neuropathy. DNA samples were genotyped for polymorphisms in the central major histocompatibility complex (MHC) near TNF, and haplotypes were derived. The haplotype group FVa6,7,8 (incorporating TNF-1031) was found to be associated with neuropathy in Chinese patients in bivariate analyses (P = 0.03), and in Malays and Chinese in a multivariate analysis correcting for age and height (P = 0.02, P = 0.03, respectively). This trend was also confirmed in Caucasians. © 2010 John Wiley & Sons A/S.

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