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    Topical and cutaneous delivery using nanosystems

    Access Status
    Fulltext not available
    Authors
    Roberts, M.
    Mohammed, Y.
    Pastore, M.
    Namjoshi, S.
    Yousef, S.
    Alinaghi, A.
    Haridass, I.
    Abd, E.
    Leite-Silva, V.
    Benson, Heather
    Grice, J.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Roberts, M. and Mohammed, Y. and Pastore, M. and Namjoshi, S. and Yousef, S. and Alinaghi, A. and Haridass, I. et al. 2017. Topical and cutaneous delivery using nanosystems. Journal of Controlled Release. 247: pp. 86-105.
    Source Title
    Journal of Controlled Release
    DOI
    10.1016/j.jconrel.2016.12.022
    ISSN
    0168-3659
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/47450
    Collection
    • Curtin Research Publications
    Abstract

    The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review.

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