Topical and cutaneous delivery using nanosystems
MetadataShow full item record
The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review.
Showing items related by title, author, creator and subject.
Changes in caesarean delivery rates in Western Australia from 1995 to 2010 by gestational age at birthEinarsdöttir, K.; Ball, Stephen; Pereira, Gavin; Griffin, C.; Jacoby, P.; De Klerk, N.; Leonard, H.; Stanley, F. (2015)© 2015 John Wiley & Sons Ltd. Background The caesarean delivery rate in the developed world has been increasing. It is not well understood how caesarean delivery rates have changed by gestational age at birth in Western ...
Tan, K.; Danquah, M.; Sidhu, Amandeep; Yon, L.; Ongkudon, C. (2016)© 2016 Bentham Science Publishers.The search for smart delivery systems for enhanced pre-clinical and clinical pharmaceutical delivery and cell targeting continues to be a major biomedical research endeavor owing to ...
Prevalence and factors associated with non-utilization of healthcare facility for childbirth in rural and urban Nigeria: Analysis of a national population-based surveyAdewuyi, E.; Zhao, Yun; Auta, A.; Lamichhane, R. (2017)© Author(s) 2017. Aim: The aim of this study was to assess the rural-urban differences in the prevalence and factors associated with non-utilization of healthcare facility for childbirth (home delivery) in Nigeria. Methods: ...