The multifaceted role of curcumin in cancer prevention and treatment
MetadataShow full item record
Despite significant advances in treatment modalities over the last decade, neither the incidence of the disease nor the mortality due to cancer has altered in the last thirty years. Available anti-cancer drugs exhibit limited efficacy, associated with severe side effects, and are also expensive. Thus identification of pharmacological agents that do not have these disadvantages is required. Curcumin, a polyphenolic compound derived from turmeric (Curcumin longa), is one such agent that has been extensively studied over the last three to four decades for its potential anti-inflammatory and/or anti-cancer effects. Curcumin has been found to suppress initiation, progression, and metastasis of a variety of tumors. These anti-cancer effects are predominantly mediated through its negative regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other oncogenic molecules. It also abrogates proliferation of cancer cells by arresting them at different phases of the cell cycle and/or by inducing their apoptosis. The current review focuses on the diverse molecular targets modulated by curcumin that contribute to its efficacy against various human cancers.
This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Showing items related by title, author, creator and subject.
Kurniawansyan, F.; Duong, H.; Danh, L.; Mammucari, R.; Vittorio, O.; Boyer, C.; Foster, Neil (2015)Inhalable formulations of curcumin with hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone have been produced by a newly developed anti-solvent micronization technique based on the supercritical fluid (SCF) technology. ...
Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s diseaseGoozee, K.; Shah, T.; Sohrabi, H.; Rainey-Smith, S.; Brown, B.; Verdile, Giuseppe; Martins, R. (2015)Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties ...
Kovacevic, Z.; Kalinowski, D.; Lovejoy, D.; Yu, Yu; Rahmanto, Y.; Sharpe, P.; Bernhardt, P.; Richardson, D. (2011)Cancer is one of the leading causes of death worldwide and there is an increasing need for novel anti-tumor therapeutics with greater selectivity and potency. A new strategy in the treatment of cancer has focused on ...