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    Phospholipase C?1 is required for metastasis development and progression

    Access Status
    Open access via publisher
    Authors
    Sala, G.
    Dituri, F.
    Raimondi, C.
    Previdi, S.
    Maffucci, T.
    Mazzoletti, M.
    Rossi, C.
    Iezzi, M.
    Lattanzio, R.
    Piantelli, M.
    Iacobelli, S.
    Broggini, M.
    Falasca, Marco
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Sala, G. and Dituri, F. and Raimondi, C. and Previdi, S. and Maffucci, T. and Mazzoletti, M. and Rossi, C. et al. 2008. Phospholipase C?1 is required for metastasis development and progression. Cancer Research. 68 (24): pp. 10187-10196.
    Source Title
    Cancer Research
    DOI
    10.1158/0008-5472.CAN-08-1181
    ISSN
    0008-5472
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/48174
    Collection
    • Curtin Research Publications
    Abstract

    Cell motility and invasion play an essential role in the development of metastasis. Evidence suggests that the enzyme phospholipase C?1 (PLC?1) may be involved in tumor progression and possibly development of metastasis. In this study, we show that down-regulation of PLC?1 expression severely impairs activation of the small GTP-binding protein Rac and cell invasion in breast cancer cell lines and U87 in vitro. Experimental metastasis assays in nude mice show that inducible knockdown of PLC?1 strongly inhibits development of MDA-MB-231-derived lung metastasis and reverts metastasis formation. In addition, analysis of 60 breast cancer patients' tissues revealed an increase of PLC?1 expression in metastasis compared with the primary tumor in 50% of tissues analyzed. These data showa critical role of PLC?1 in the metastatic potential of cancer cells, and they further indicate that PLC?1 inhibition has a therapeutic potential in the treatment of metastasis dissemination. ©2008 American Association for Cancer Research.

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