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    Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy.

    246939.pdf (331.4Kb)
    Access Status
    Open access
    Authors
    Marini, S.
    Susufi, Y.
    Krisnuhoni, E.
    Gani, R.
    Yunihastuti, E.
    Lee, Silvia
    Tanaskovic, S.
    Price, Patricia
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Stephanie, M. and Susufi, Y. and Krisnuhoni, E. and Gani, R. and Yunihastuti, E. and Lee, S. and Tanaskovic, S. et al. 2016. Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. AIDS Research and Human Retroviruses. 32 (12): pp. 1202-1204.
    Source Title
    AIDS Research and Human Retroviruses
    DOI
    10.1089/AID.2016.0042
    School
    School of Biomedical Sciences
    Remarks

    Final publication is available from Mary Ann Liebert, Inc., publishers http://doi.org/10.1089/AID.2016.0042

    URI
    http://hdl.handle.net/20.500.11937/48277
    Collection
    • Curtin Research Publications
    Abstract

    Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4(+) and CD8(+) cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART.

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