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dc.contributor.authorIkuta, S.
dc.contributor.authorChuang, Victor
dc.contributor.authorIshima, Y.
dc.contributor.authorNakajou, K.
dc.contributor.authorFurukawa, M.
dc.contributor.authorWatanabe, H.
dc.contributor.authorMaruyama, T.
dc.contributor.authorOtagiri, M.
dc.date.accessioned2017-01-30T15:38:47Z
dc.date.available2017-01-30T15:38:47Z
dc.date.created2016-09-22T12:04:54Z
dc.date.issued2010
dc.identifier.citationIkuta, S. and Chuang, V. and Ishima, Y. and Nakajou, K. and Furukawa, M. and Watanabe, H. and Maruyama, T. et al. 2010. Albumin fusion of thioredoxin - The production and evaluation of its biological activity for potential therapeutic applications. Journal of Controlled Release. 147: pp. 17-23.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/48314
dc.identifier.doi10.1016/j.jconrel.2010.05.020
dc.description.abstract

Thioredoxin-1 (Trx) is a redox-active protein with anti-inflammatory effects. The effect of albumin fusion on the pharmacokinetic and pharmacodynamic properties of Trx was evaluated in this study. The findings indicate that the properties of human serum albumin and the fusion protein are comparable. The fusion protein showed similar plasma concentration and organ distribution profiles as human serum albumin. The fusion protein accumulated in lungs, reaching levels higher than Trx. In an insulin reducing assay, the activity of the fusion protein was 60% of the activity of Trx. However, survival rate of endotoxic shock mice induced by the administration of a lipopolysaccharide and D-galactosamine for fusion protein was double that of Trx. The findings reported herein indicate that the fusion protein is likely to have great clinical applications in areas such as the treatment of reperfusion injuries.

dc.publisherElsevier
dc.titleAlbumin fusion of thioredoxin - The production and evaluation of its biological activity for potential therapeutic applications
dc.typeJournal Article
dcterms.source.volume147
dcterms.source.startPage17
dcterms.source.endPage23
dcterms.source.issn0168-3659
dcterms.source.titleJournal of Controlled Release
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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