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    Parallel changes in cortical neuron biochemistry and motor function in protein-energy malnourished adult rats

    Access Status
    Fulltext not available
    Authors
    Alaverdashvili, M.
    Hackett, Mark
    Caine, S.
    Paterson, P.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Alaverdashvili, M. and Hackett, M. and Caine, S. and Paterson, P. 2017. Parallel changes in cortical neuron biochemistry and motor function in protein-energy malnourished adult rats. NeuroImage. 149: pp. 275-284.
    Source Title
    NeuroImage
    DOI
    10.1016/j.neuroimage.2017.02.010
    ISSN
    1053-8119
    School
    Department of Chemistry
    URI
    http://hdl.handle.net/20.500.11937/48917
    Collection
    • Curtin Research Publications
    Abstract

    While protein-energy malnutrition in the adult has been reported to induce motor abnormalities and exaggerate motor deficits caused by stroke, it is not known if alterations in mature cortical neurons contribute to the functional deficits. Therefore, we explored if PEM in adult rats provoked changes in the biochemical profile of neurons in the forelimb and hindlimb regions of the motor cortex. Fourier transform infrared spectroscopic imaging using a synchrotron generated light source revealed for the first time altered lipid composition in neurons and subcellular domains (cytosol and nuclei) in a cortical layer and region-specific manner. This change measured by the area under the curve of the d(CH2) band may indicate modifications in membrane fluidity. These PEM-induced biochemical changes were associated with the development of abnormalities in forelimb use and posture. The findings of this study provide a mechanism by which PEM, if not treated, could exacerbate the course of various neurological disorders and diminish treatment efficacy.

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