Synthesis, morphological structures and material characterization of electrospun PLA: PCL/magnetic nanoparticle composites for drug delivery
MetadataShow full item record
The effects of pure and impure magnetic nanoparticles (MPs) with three different concentrations (0.01, 0.1 and 1 wt%/v) on the morphological structure, crystallinity level, thermal properties and constituent interactions of electrospun poly(lactic acid) (PLA): poly(e-caprolactone) (PCL) based composites were investigated by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR) and drug release tests using UV–vis spectrophotometry. Tetracycline hydrochloride (TCH), as a typical therapeutic compound, was loaded into these composite fibrous structures to study their application for drug delivery. The infrared spectra of composite nanofibers confirm the successful embedding of MPs into the fibrous networks. The addition of pure MPs increased the solution viscosity and thus promoted the MP dispersion inside the electrospun composite fiber mats. Impure MPs led to considerably lower average fiber diameters, and could generate unique cell structures that were reported for the first time in this study. The accelerated release of TCH was found by adding pure MPs to PLA: PCL blends. This characteristic was reflected in the parameters of Ritger-Peppas and Zeng models, which were well fitted to our experimental drug release data.
Showing items related by title, author, creator and subject.
Exploring the micro-politics of normalised drug use in the social lives of a group of young 'party drug' users in Melbourne, AustraliaPennay, Amy (2012)Young people today live in what some scholars and commentators have defined as a 'post-modern' era, characterised by globalisation, the internet, mass media, production and consumption. Post-modernity has seen a change ...
An ethnographic study of recreational drug use and identity management among a network of electronic dance music enthusiasts in Perth, Western AustraliaGreen, Rachael Renee (2012)This thesis explores the social contexts and cultural significance of amphetamine-type stimulant (ATS) and alcohol use among a social network of young adults in Perth, Western Australia. The study is positioned by the ...
Synthesis, morphological structures and material characterization of electrospun PLA: PCL/magnetic nanoparticle composites for drug deliveryHaroosh, Hazim Jasim Mohammed; Dong, Yu; Ingram, Gordon (2013)The effects of pure and impure magnetic nanoparticles (MPs) with three different concentrations (0.01, 0.1 and 1 wt%/v) on the morphological structure, crystallinity level, thermal properties and constituent interactions ...