Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Synthesis, morphological structures and material characterization of electrospun PLA: PCL/magnetic nanoparticle composites for drug delivery

    249355.pdf (1.135Mb)
    Access Status
    Open access
    Authors
    Haroosh, Hazim
    Dong, Yu
    Ingram, Gordon
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Haroosh, H.J.M. and Dong, Y. and Ingram, G. 2013. Synthesis, morphological structures and material characterization of electrospun PLA: PCL/magnetic nanoparticle composites for drug delivery. Journal of Polymer Science, Part B : Polymer Physics. 51 (22): pp. 1607-1617.
    Source Title
    Journal of Polymer Science, Part B : Polymer Physics
    DOI
    10.1002/polb.23374
    ISSN
    08876266
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/49176
    Collection
    • Curtin Research Publications
    Abstract

    The effects of pure and impure magnetic nanoparticles (MPs) with three different concentrations (0.01, 0.1 and 1 wt%/v) on the morphological structure, crystallinity level, thermal properties and constituent interactions of electrospun poly(lactic acid) (PLA): poly(e-caprolactone) (PCL) based composites were investigated by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR) and drug release tests using UV–vis spectrophotometry. Tetracycline hydrochloride (TCH), as a typical therapeutic compound, was loaded into these composite fibrous structures to study their application for drug delivery. The infrared spectra of composite nanofibers confirm the successful embedding of MPs into the fibrous networks. The addition of pure MPs increased the solution viscosity and thus promoted the MP dispersion inside the electrospun composite fiber mats. Impure MPs led to considerably lower average fiber diameters, and could generate unique cell structures that were reported for the first time in this study. The accelerated release of TCH was found by adding pure MPs to PLA: PCL blends. This characteristic was reflected in the parameters of Ritger-Peppas and Zeng models, which were well fitted to our experimental drug release data.

    Related items

    Showing items related by title, author, creator and subject.

    • Editorial: Biodegradable Matrices and Composites
      Pegoretti, Alessandro; Dong, Roger ; Slouf, Miroslav (2020)
      Biodegradable and ecofriendly materials attract an increasingly high attention from polymer and composite researchers and manufactures as they can contribute to a more sustainable global development policy, to significantly ...
    • Biodegradable Matrices and Composites
      Pegoretti, Alessandro; Dong, Roger; Slouf, Miroslav; Dong, Roger [0000-0003-1774-1553]; Dong, Roger [B-1288-2009]; Dong, Roger [56816074000] (2020)
      Biodegradable and ecofriendly materials attract an increasingly high attention from polymer and composite researchers and manufactures as they can contribute to a more sustainable global development policy, to significantly ...
    • Exploring the micro-politics of normalised drug use in the social lives of a group of young 'party drug' users in Melbourne, Australia
      Pennay, Amy (2012)
      Young people today live in what some scholars and commentators have defined as a 'post-modern' era, characterised by globalisation, the internet, mass media, production and consumption. Post-modernity has seen a change ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.