Establishing the Melbourne injecting drug user cohort study (MIX): rationale, methods, and baseline and twelve-month follow-up results
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Background: Cohort studies provide an excellent opportunity to monitor changes in behaviour and diseasetransmission over time. In Australia, cohort studies of people who inject drugs (PWID) have generally focused onolder, in-treatment injectors, with only limited outcome measure data collected. In this study we specifically soughtto recruit a sample of younger, largely out-of-treatment PWID, in order to study the trajectories of their drug useover time.Methods: Respondent driven sampling, traditional snowball sampling and street outreach methods were used torecruit heroin and amphetamine injectors from one outer-urban and two inner-urban regions of Melbourne,Australia. Information was collected on participants’ demographic and social characteristics, drug use characteristics,drug market access patterns, health and social functioning, and health service utilisation. Participants are followedupon an annual basis.Results: 688 PWID were recruited into the study. At baseline, the median age of participants was 27.6 years (IQR:24.4 years – 29.6 years) and two-thirds (67%) were male. Participants reported injecting for a median of 10.2 years(range: 1.5 months – 21.2 years), with 11% having injected for three years or less. Limited education,unemployment and previous incarceration were common. The majority of participants (82%) reported recent heroininjection, and one third reported being enrolled in Opioid Substitution Therapy (OST) at recruitment. At 12 monthsfollow-up 458 participants (71% of eligible participants) were retained in the study. There were few differences indemographic and drug-use characteristics of those lost to follow-up compared with those retained in the study,with attrition significantly associated with recruitment at an inner-urban location, male gender, and providingincomplete contact information at baseline.Conclusions: Our efforts to recruit a sample of largely out-of-treatment PWID were limited by drug marketcharacteristics at the time, where fluctuating heroin availability has led to large numbers of PWID accessing lowthresholdOST. Nevertheless, this study of Australian injectors will provide valuable data on the natural history ofdrug use, along with risk and protective factors for adverse health outcomes associated with injecting drug use.Comprehensive follow-up procedures have led to good participant retention and limited attrition bias.
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