Development of Affordable Effective Vaccines against Whooping Cough for the Developing World
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The rate of mortality in children associated with serious infectious diseases is significantly higher in the developing world and in socioeconomically disadvantaged populations in developed industrialized countries. The reasons underpinning the higher incidence of whooping cough (pertussis) in these populations include overcrowding and poor hygiene, poor coverage with available pertussis containing vaccines and waning immunity following immunisation and infection. Two types of vaccines are currently used for vaccinating infants and children. The whole cell pertussis vaccine, the most used vaccine worldwide, consisting of a killed B pertussis strain, origin of which may differ in different countries, is generally given in combination with chemically or genetically inactivated diphtheria and tetanus toxoids [DTwP or DTPw], with or without combination with Haemophilus influenzae type b [Hib], hepatitis B or inactivated polio virus vaccine [IPV], depending upon the vaccine manufacturer.
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The impact of parental postpartum pertussis vaccination on infection in infants: A population-based study of cocooning in Western AustraliaCarcione, D.; Regan, Annette; Tracey, L.; Mak, D.; Gibbs, R.; Dowse, G.; Bulsara, M.; Effler, P. (2015)During a pertussis epidemic in 2011–2012 the Western Australian (WA) Department of Health implemented a ‘cocooning’ programme, offering free pertussis-containing vaccine (dTpa) to new parents. We assessed the impact of ...
Regan, Annette; Hauck, Yvonne; Nicolaou, L.; Engelbrecht, D.; Butt, J.; Mak, D.; Priest, R.; Cukierman, R.; Effler, P. (2018)Objective: To determine the knowledge, attitudes and learning needs of midwives regarding antenatal vaccination. Design and setting: A cross-sectional, paper-based survey of midwives employed at the only public tertiary ...
Transiently increased IgE responses in infants and pre-schoolers receiving only acellular Diphtheria–Pertussis–Tetanus (DTaP) vaccines compared to those initially receiving at least one dose of cellular vaccine (DTwP) – Immunological curiosity or canary in the mine?Holt, P.; Snelling, Thomas; White, O.; Sly, P.; DeKlerk, N.; Carapetis, J.; Biggelaar, A.; Wood, N.; McIntyre, P.; Gold, M. (2016)© 2016 Elsevier Ltd Background Several previous studies have highlighted the strong Th2-polarising and IgE-promoting activity of the DTaP vaccine, but there is no evidence that this has pathological consequences and ...