The use of agonistic anti-CD40 therapy in treatments for cancer
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Agonistic anti-CD40 antibody is a potent stimulator of anti-tumor immune responses due to itsaction on both immuneand tumor cells. It has the ability to “precondition” dendritic cells, allowingthem to prime effective cytotoxic T-cell responses. Thus, anti-CD40 antibody provides an idealtherapy for combination with traditional cancer treatments (i.e., chemotherapy, surgery) in orderto elicit immune-mediated anti-tumor effects. This review summarizes the mechanisms of actionof agonistic anti-CD40, the use of mouse models to investigate its effects and combinations withother therapies in vivo, and current clinical trials combining humanized anti-CD40 antibody withchemotherapy and/or other immunotherapies.
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Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ - independent resolution of treated-turmors and CD4+ -dependent systemic and memory responsesJackaman, Connie; Nelson, Delia (2012)Targeting interleukin-2 (IL-2) and/or agonist anti-CD40 antibody (Ab) into tumors represents an effective vaccination strategy that avoids systemic toxicity and resolves treated-site tumors. Here, we examined IL-2 and/or ...
Jackaman, Connie; Radley-Crabb, Hannah; Soffe, Z.; Shavlakadze, T.; Grounds, M.; Nelson, Delia (2013)Changes to innate cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), during aging in healthy or tumor-bearing hosts are not well understood. We compared macrophage subpopulations and MDSCs from healthy ...
Jackaman, Connie; Dye, Danielle; Nelson, Delia (2014)The role of macrophages and their interactions with T cells during aging is not well understood. We determined if activating elderly-derived macrophages could rescue age-related and tumor-induced T cell dysfunction. Healthy ...