Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The use of agonistic anti-CD40 therapy in treatments for cancer

    Access Status
    Fulltext not available
    Authors
    Khong, A.
    Nelson, Delia
    nowak, A.
    Lake, R.
    Robinson, B.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Khong, A. and Nelson, D. and nowak, A. and Lake, R. and Robinson, B. 2012. The use of agonistic anti-CD40 therapy in treatments for cancer. International Reviews of Immunology. 31: pp. 246-266.
    Source Title
    International Reviews of Immunology
    Additional URLs
    http://informahealthcare.com/loi/iri
    ISSN
    08830185
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/49580
    Collection
    • Curtin Research Publications
    Abstract

    Agonistic anti-CD40 antibody is a potent stimulator of anti-tumor immune responses due to itsaction on both immuneand tumor cells. It has the ability to “precondition” dendritic cells, allowingthem to prime effective cytotoxic T-cell responses. Thus, anti-CD40 antibody provides an idealtherapy for combination with traditional cancer treatments (i.e., chemotherapy, surgery) in orderto elicit immune-mediated anti-tumor effects. This review summarizes the mechanisms of actionof agonistic anti-CD40, the use of mouse models to investigate its effects and combinations withother therapies in vivo, and current clinical trials combining humanized anti-CD40 antibody withchemotherapy and/or other immunotherapies.

    Related items

    Showing items related by title, author, creator and subject.

    • Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ - independent resolution of treated-turmors and CD4+ -dependent systemic and memory responses
      Jackaman, Connie; Nelson, Delia (2012)
      Targeting interleukin-2 (IL-2) and/or agonist anti-CD40 antibody (Ab) into tumors represents an effective vaccination strategy that avoids systemic toxicity and resolves treated-site tumors. Here, we examined IL-2 and/or ...
    • Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
      Jackaman, Connie; Radley-Crabb, Hannah; Soffe, Z.; Shavlakadze, T.; Grounds, M.; Nelson, Delia (2013)
      Changes to innate cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), during aging in healthy or tumor-bearing hosts are not well understood. We compared macrophage subpopulations and MDSCs from healthy ...
    • Murine mesothelioma induces locally-proliferating IL-10+TNF-a+CD206-CX3CR1+ M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy
      Jackaman, Connie; Yeoh, T.; Acuil, M.; Gardner, Joanne; Nelson, Delia (2016)
      © 2016 Taylor & Francis Group, LLC.We used a murine model to monitor changes to myeloid cell subsets, i.e., myeloid-derived suppressor cells (MDSCs), M1 macrophages that secrete pro-inflammatory cytokines and express CD40 ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.