Show simple item record

dc.contributor.authorShanmugam, M.
dc.contributor.authorNguyen, A.
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorTan, B.
dc.contributor.authorSethi, G.
dc.date.accessioned2017-03-15T22:16:20Z
dc.date.available2017-03-15T22:16:20Z
dc.date.created2017-02-26T19:31:38Z
dc.date.issued2012
dc.identifier.citationShanmugam, M. and Nguyen, A. and Kumar, A.P. and Tan, B. and Sethi, G. 2012. Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer. Cancer Letters. 320 (2): pp. 158-170.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/49782
dc.identifier.doi10.1016/j.canlet.2012.02.037
dc.description.abstract

Over the last two decades, extensive research on plant-based medicinal compounds has revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits, vegetables, cereals, pulses, herbs and medicinal plants are all considered to be biological sources of these triterpenoids, which have attracted great attention especially for their potent anti-inflammatory and anti-cancer activities. Published reports in the past have described the molecular mechanism(s) underlying the various biological activities of triterpenoids which range from inhibition of acute and chronic inflammation, inhibition of tumor cell proliferation, induction of apoptosis, suppression of angiogenesis and metastasis. However systematic analysis of various pharmacological properties of these important classes of compounds has not been done. In this review, we describe in detail the pre-clinical chemopreventive and therapeutic properties of selected triterpenoids that inhibit multiple intracellular signaling molecules and transcription factors involved in the initiation, progression and promotion of various cancers. Molecular targets modulated by these triterpenoids comprise, cytokines, chemokines, reactive oxygen intermediates, oncogenes, inflammatory enzymes such as COX-2, 5-LOX and MMPs, anti-apoptotic proteins, transcription factors such as NF-κB, STAT3, AP-1, CREB, and Nrf2 (nuclear factor erythroid 2-related factor) that regulate tumor cell proliferation, transformation, survival, invasion, angiogenesis, metastasis, chemoresistance and radioresistance. Finally, this review also analyzes the potential role of novel synthetic triterpenoids identified recently which mimic natural triterpenoids in physical and chemical properties and are moving rapidly from bench to bedside research.

dc.publisherElsevier
dc.titleTargeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
dc.typeJournal Article
dcterms.source.volume320
dcterms.source.number2
dcterms.source.startPage158
dcterms.source.endPage170
dcterms.source.issn0304-3835
dcterms.source.titleCancer Letters
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record