Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Rationale and design of the European Polyp Surveillance (EPoS) trials

    Access Status
    Fulltext not available
    Authors
    Jover, R.
    Bretthauer, M.
    Dekker, E.
    Holme, O.
    Kaminski, M.
    Loberg, M.
    Zauber, A.
    Hernán, M.
    Lansdorp-Vogelaar, Iris
    Sunde, A.
    McFadden, E.
    Castells, A.
    Regula, J.
    Quintero, E.
    Pellisé, M.
    Senore, C.
    Kalager, M.
    Dinis-Ribeiro, M.
    Emilsson, L.
    Ransohoff, D.
    Hoff, G.
    Adami, H.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Jover, R. and Bretthauer, M. and Dekker, E. and Holme, O. and Kaminski, M. and Loberg, M. and Zauber, A. et al. 2016. Rationale and design of the European Polyp Surveillance (EPoS) trials. Endoscopy. 48 (6): pp. 571-578.
    Source Title
    Endoscopy
    DOI
    10.1055/s-0042-104116
    ISSN
    0013-726X
    URI
    http://hdl.handle.net/20.500.11937/49808
    Collection
    • Curtin Research Publications
    Abstract

    Background: Current guidelines recommend surveillance colonoscopies after polyp removal depending on the number and characteristics of polyps, but there is a lack of evidence supporting the recommendations. This report outlines the rationale and design of two randomized trials and one observational study investigating evidence-based surveillance strategies following polyp removal. Study design and endpoints: The EPoS studies started to recruit patients in April 2015. EPoS study I randomizes 13 746 patients with low-risk adenomas (1 – 2 tubular adenomas size < 10 mm, low-grade dysplasia) to surveillance after 5 and 10 years, or 10 years only. EPoS study II randomizes 13 704 patients with high-risk adenomas (3 – 10 adenomas or adenoma ≥ 10 mm in diameter, or adenoma with high-grade dysplasia, or > 25 % villous features) to surveillance after 3, 5, and 10 years, or 5 and 10 years only. EPoS study III offers surveillance after 5 and 10 years to patients with serrated polyps ≥ 10 mm in diameter at any location, or serrated polyps ≥ 5 mm in diameter proximal to the splenic flexure. All polyps are removed before patients enter the trials. The primary end point is colorectal cancer incidence after 10 years. We assume a colorectal cancer risk of 1 % for patients in EPoS I, and 2 % for patients in EPoS II. Using a noninferiority hypothesis with an equivalence interval of 0.5 % for EPoS I and 0.7 % for EPoS II, the trials are 90 % powered to uncover differences larger than the equivalence intervals. For EPoS III, no power analyses have been performed.

    Related items

    Showing items related by title, author, creator and subject.

    • Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths
      Zauber, A.; Winawer, S.; O'Brien, M.; Lansdorp_Vogelaar, Iris; Van Ballegooijen, M.; Hankey, B.; Shi, W.; Bond, J.; Schapiro, M.; Panish, J.; Stewart, E.; Waye, J. (2012)
      BACKGROUND: In the National Polyp Study (NPS), colorectal cancer was prevented by colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of colonoscopic polypectomy in a study on mortality from ...
    • Utilization of surveillance after Polypectomy in the Medicare population - A cohort study
      Lansdorp_Vogelaar, Iris; Fedewa, S.; Lin, C.; Virgo, K.; Jemal, A. (2014)
      Background: Surveillance in patients with previous polypectomy was underused in the Medicare population in 1994. This study investigates whether expansion of Medicare reimbursement for colonoscopy screening in high-risk ...
    • Developing a score chart to improve risk stratification of patients with colorectal adenoma
      Van Heijningen, E.; Lansdorp_Vogelaar, Iris; Van Hees, F.; Kuipers, E.; Biermann, K.; De Koning, H.; Van Ballegooijen, M.; Steyerberg, E. (2016)
      Background and study aims: Current surveillance guidelines risk stratify patients with adenoma by using only one or two factors: adenoma multiplicity or presence of an advanced adenoma characteristic. Combinations of ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.