Show simple item record

dc.contributor.authorKapidzic, A.
dc.contributor.authorvan Roon, A.
dc.contributor.authorvan Leerdam, M.
dc.contributor.authorvan Vuuren, A.
dc.contributor.authorvan Ballegooijen, M.
dc.contributor.authorLansdorp-Vogelaar, Iris
dc.contributor.authorSpijker, W.
dc.contributor.authorIzelaar, K.
dc.contributor.authorHol, L.
dc.contributor.authorKuipers, E.
dc.identifier.citationKapidzic, A. and van Roon, A. and van Leerdam, M. and van Vuuren, A. and van Ballegooijen, M. and Lansdorp-Vogelaar, I. and Spijker, W. et al. 2015. Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer. Gut. 66 (1): pp. 118-123.

Objective: Limited data exist on attendance and additional yield of 2-sample faecal immunochemical testing (FIT) screening during multiple rounds. We therefore conducted a population-based colorectal cancer screening trial comparing attendance and yield of repeated 1-sample and 2-sample FIT screenings. Design: Two randomly selected groups of average-risk subjects aged 50-74 years were invited for two rounds of either 1-sample (n=5007) or 2-sample (n=3197) FIT (OC-sensor Micro) screening. The test was considered positive if at least one sample was positive (cut-off 50 ng/mL; 10 µg haemoglobin/g). Results: The cumulative attendance rate was similar for repeated 1-sample and 2-sample FIT screenings (1-sample FIT: 68.1%; 2-sample FIT: 67.1%, p=0.368). The positivity rate in the second round was lower for 1-sample FIT (6.2%, 95% CI 5.4% to 7.2%) than for 2-sample FIT (8.4%, 95% CI 7.1% to 9.8%, p=0.007), whereas the detection rate of advanced neoplasia (AN, 1-sample FIT: 1.9%, 95% CI 1.2% to 2.2%; 2-sample FIT: 1.7%, 95% CI 1.2% to 2.5%, p=0.861) and the positive predictive value (1-sample FIT: 32%, 95% CI 24% to 40%; 2-sample FIT: 21%, 95% CI 15% to 29%, p=0.075) did not differ. After two rounds of screening, the cumulative diagnostic yield of AN for 1-sample FIT was 29.3 per 1000 invitees, compared with 34.0 for 2-sample FIT (p=0.241). Conclusions: Using 2-sample FIT instead of 1-sample FIT does not result in a higher detection rate of AN in the second round of repeated FIT screening. Furthermore, both strategies lead to a similar yield of AN over two rounds. These findings imply that 1-sample FIT screening is preferred over 2-sample FIT screening.

dc.titleAttendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer
dc.typeJournal Article
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record