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    Micro-PIV and CFD studies show non-uniform wall shear stress distributions over endothelial cells

    Access Status
    Fulltext not available
    Authors
    Dol, Sharul sham
    Salek, M.
    Viegas, K.
    Rinker, K.
    Martinuzzi, R.
    Date
    2010
    Type
    Conference Paper
    
    Metadata
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    Citation
    Dol, S.S. and Salek, M. and Viegas, K. and Rinker, K. and Martinuzzi, R. 2010. Micro-PIV and CFD studies show non-uniform wall shear stress distributions over endothelial cells, pp. 31-39.
    Source Title
    ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels Collocated with 3rd Joint US-European Fluids Engineering Summer Meeting, ICNMM2010
    DOI
    10.1115/FEDSM-ICNMM2010-30605
    ISBN
    9780791854501
    School
    Curtin Sarawak
    URI
    http://hdl.handle.net/20.500.11937/4987
    Collection
    • Curtin Research Publications
    Abstract

    Wall shear stress acting on arterial walls is an important hemodynamic force determining vessel health. A parallel-plate flow chamber with a 127 µm-thick flow channel is used as an in vitro system to study the fluid mechanics environment. It is essential to know how well this flow chamber performs in emulating physiologic flow regimes especially when cultured cells are present. Hence, the objectives of this work are to computationally and experimentally study the characteristic of the flow chamber in providing a defined flow regime and shear stress to cultured cells and to map wall shear stress distributions in the presence of an endothelial cell layer. Experiments and modeling were performed for the nominal wall shear stresses of 2 and 10 dyn/cm2. Without endothelial cells, the flow field is uniform over 95% of the chamber cross-section and the surfaces are exposed to the target stress level. Using PIV velocity data, the endothelial cell surfaces were re-constructed and flow over these surfaces was then simulated via FLUENT. Once endothelial cells are introduced, local shear variations are large and the velocity profiles are no longer uniform. Due to the velocity distribution between peaks and valleys, the local wall shear stresses range between 47-164% of the nominal values. This study demonstrates the non-uniform shear stress distribution over the cells is non-negligible especially in small vessels or where blockage is important. Copyright © 2010 by ASME.

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