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    Should colorectal cancer screening be considered in elderly persons without previous screening?: A cost-effectiveness analysis

    Access Status
    Fulltext not available
    Authors
    Van Hees, F.
    Habbema, D.
    Meester, R.
    Lansdorp_Vogelaar, Iris
    Van Ballegooijen, M.
    Zauber, A.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Van Hees, F. and Habbema, D. and Meester, R. and Lansdorp_Vogelaar, I. and Van Ballegooijen, M. and Zauber, A. 2014. Should colorectal cancer screening be considered in elderly persons without previous screening?: A cost-effectiveness analysis. Annals of Internal Medicine. 160 (11): pp. 750-759.
    Source Title
    Annals of Internal Medicine
    DOI
    10.7326/M13-2263
    ISSN
    0003-4819
    URI
    http://hdl.handle.net/20.500.11937/49910
    Collection
    • Curtin Research Publications
    Abstract

    Background: The U.S. Preventive Services Task Force recommends against routine screening for colorectal cancer (CRC) in adequately screened persons older than 75 years but does not address the appropriateness of screening in elderly persons without previous screening. Objective: To determine at what ages CRC screening should be considered in unscreened elderly persons and to determine which test is indicated at each age. Design: Microsimulation modeling study. Data Sources: Observational and experimental studies. Target Population: Unscreened persons aged 76 to 90 years with no, moderate, and severe comorbid conditions. Time Horizon: Lifetime. Perspective: Societal. Intervention: One-time colonoscopy, sigmoidoscopy, or fecal immunochemical test (FIT) screening. Outcome Measures: Quality-adjusted life-years gained, costs, and costs per quality-adjusted life-year gained. Results of Base-Case Analysis: In unscreened elderly persons with no comorbid conditions, CRC screening was cost-effective up to age 86 years. Screening with colonoscopy was indicated up to age 83 years, sigmoidoscopy was indicated at age 84 years, and FIT was indicated at ages 85 and 86 years. In unscreened persons with moderate comorbid conditions, screening was cost-effective up to age 83 years (colonoscopy indicated up to age 80 years, sigmoidoscopy at age 81 years, and FIT at ages 82 and 83 years). In unscreened persons with severe comorbid conditions, screening was cost-effective up to age 80 years (colonoscopy indicated up to age 77 years, sigmoidoscopy at age 78 years, and FIT at ages 79 and 80 years). Results of Sensitivity Analyses: Results were most sensitive to assuming a lower willingness to pay per quality-adjusted life-year gained. Limitation: Only persons at average risk for CRC were considered. Conclusion: In unscreened elderly persons CRC screening should be considered well beyond age 75 years. A colonoscopy is indicated at most ages. © 2014 American College of Physicians.

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