A randomised comparison of two faecal immunochemical tests in population-based colorectal cancer screening
dc.contributor.author | Grobbee, E. | |
dc.contributor.author | van der Vlugt, M. | |
dc.contributor.author | van Vuuren, A. | |
dc.contributor.author | Stroobants, A. | |
dc.contributor.author | Mundt, M. | |
dc.contributor.author | Spijker, W. | |
dc.contributor.author | Bongers, E. | |
dc.contributor.author | Kuipers, E. | |
dc.contributor.author | Lansdorp_Vogelaar, Iris | |
dc.contributor.author | Bossuyt, P. | |
dc.contributor.author | Dekker, E. | |
dc.contributor.author | Spaander, M. | |
dc.date.accessioned | 2017-03-15T22:16:52Z | |
dc.date.available | 2017-03-15T22:16:52Z | |
dc.date.created | 2017-02-26T19:31:41Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Grobbee, E. and van der Vlugt, M. and van Vuuren, A. and Stroobants, A. and Mundt, M. and Spijker, W. and Bongers, E. et al. 2016. A randomised comparison of two faecal immunochemical tests in population-based colorectal cancer screening. Gut. 66: pp. 1975-1982. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/49962 | |
dc.identifier.doi | 10.1136/gutjnl-2016-311819 | |
dc.description.abstract |
Objective: Colorectal cancer screening programmes are implemented worldwide; many are based on faecal immunochemical testing (FIT). The aim of this study was to evaluate two frequently used FITs on participation, usability, positivity rate and diagnostic yield in population-based FIT screening. Design: Comparison of two FITs was performed in a fourth round population-based FIT-screening cohort. Randomly selected individuals aged 50-74 were invited for FIT screening and were randomly allocated to receive an OC -Sensor (Eiken, Japan) or faecal occult blood (FOB)-Gold (Sentinel, Italy) test (March-December 2014). A cut-off of 10 µg haemoglobin (Hb)/g faeces (ie, 50 ng Hb/mL buffer for OC-Sensor and 59 ng Hb for FOB-Gold) was used for both FITs. Results: In total, 19 291 eligible invitees were included (median age 61, IQR 57-67; 48% males): 9669 invitees received OC-Sensor and 9622 FOB-Gold; both tests were returned by 63% of invitees ( p=0.96). Tests were nonanalysable in 0.7% of participants using OC-Sensor vs 2.0% using FOB-Gold (p<0.001). Positivity rate was 7.9% for OC-Sensor, and 6.5% for FOB-Gold (p=0.002). There was no significant difference in diagnostic yield of advanced neoplasia (1.4% for OC-Sensor vs 1.2% for FOB-Gold; p=0.15) or positive predictive value (PPV; 31% vs 32%; p=0.80). When comparing both tests at the same positivity rate instead of cut-off, they yielded similar PPV and detection rates. Conclusions: The OC-Sensor and FOB-Gold were equally acceptable to a screening population. However, FOB-Gold was prone to more non-analysable tests. Comparison between FIT brands is usually done at the same Hb stool concentration. Our findings imply that for a fair comparison on diagnostic yield between FIT's positivity rate rather than Hb concentration should be used. Trial registration number: NTR5385; Results. | |
dc.title | A randomised comparison of two faecal immunochemical tests in population-based colorectal cancer screening | |
dc.type | Journal Article | |
dcterms.source.issn | 0017-5749 | |
dcterms.source.title | Gut | |
curtin.accessStatus | Fulltext not available |
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