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    Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach

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    Authors
    Arooj, Mahreen
    Sakkiah, S.
    Cao, G.
    Kim, S.
    Arulalapperumal, V.
    Lee, K.
    Date
    2015
    Type
    Journal Article
    
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    Citation
    Arooj, M. and Sakkiah, S. and Cao, G. and Kim, S. and Arulalapperumal, V. and Lee, K. 2015. Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach. Proteins: Structure, Function, Bioinformatics. 83 (7): pp. 1209-1224.
    Source Title
    Proteins: Structure, Function, Bioinformatics
    DOI
    10.1002/prot.24677
    ISSN
    0887-3585
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/50090
    Collection
    • Curtin Research Publications
    Abstract

    Off-target binding connotes the binding of a small molecule of therapeutic significance to a protein target in addition to the primary target for which it was proposed. Progressively such off-targeting is emerging to be regular practice to reveal side effects. Chymase is an enzyme of hydrolase class that catalyzes hydrolysis of peptide bonds. A link between heart failure and chymase is ascribed, and a chymase inhibitor is in clinical phase II for treatment of heart failure. However, the underlying mechanisms of the off-target effects of human chymase inhibitors are still unclear. Here, we develop a robust computational strategy that is applicable to any enzyme system and that allows the prediction of drug effects on biological processes. Putative off-targets for chymase inhibitors were identified through various structural and functional similarity analyses along with molecular docking studies. Finally, literature survey was performed to incorporate these off-targets into biological pathways and to establish links between pathways and particular adverse effects. Off-targets of chymase inhibitors are linked to various biological pathways such as classical and lectin pathways of complement system, intrinsic and extrinsic pathways of coagulation cascade, and fibrinolytic system. Tissue kallikreins, granzyme M, neutrophil elastase, and mesotrypsin are also identified as off-targets. These off-targets and their associated pathways are elucidated for the effects of inflammation, cancer, hemorrhage, thrombosis, and central nervous system diseases (Alzheimer's disease). Prospectively, our approach is helpful not only to better understand the mechanisms of chymase inhibitors but also for drug repurposing exercises to find novel uses for these inhibitors.

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