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dc.contributor.authorBadet, T.
dc.contributor.authorPeyraud, R.
dc.contributor.authorMbengue, M.
dc.contributor.authorNavaud, O.
dc.contributor.authorDerbyshire, Mark
dc.contributor.authorOliver, Richard
dc.contributor.authorBarbacci, A.
dc.contributor.authorRaffaele, S.
dc.date.accessioned2017-03-15T22:23:45Z
dc.date.available2017-03-15T22:23:45Z
dc.date.created2017-03-08T06:39:36Z
dc.date.issued2017
dc.identifier.citationBadet, T. and Peyraud, R. and Mbengue, M. and Navaud, O. and Derbyshire, M. and Oliver, R. and Barbacci, A. et al. 2017. Codon optimization underpins generalist parasitism in fungi. eLife. 6.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/50320
dc.identifier.doi10.7554/eLife.22472
dc.description.abstract

The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We found that the longer proteins encoded by broad host range fungi likely increase natural selection on codon optimization in these species. Accordingly, codon optimization correlates with host range across the fungal kingdom. At the species level, biased patterns of synonymous substitutions underpin increased codon optimization in a generalist but not a specialist fungal pathogen. Virulence genes were consistently enriched in highly codon-optimized genes of generalist but not specialist species. We conclude that codon optimization is related to the capacity of parasites to colonize multiple hosts. Our results link genome evolution and translational regulation to the long-term persistence of generalist parasitism.

dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCodon optimization underpins generalist parasitism in fungi
dc.typeJournal Article
dcterms.source.volume6
dcterms.source.issn2050-084X
dcterms.source.titleeLife
curtin.departmentCentre for Crop Disease Management
curtin.accessStatusOpen access


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