Show simple item record

dc.contributor.authorCai, W.
dc.contributor.authorXiong Chen, Z.
dc.contributor.authorRane, G.
dc.contributor.authorSatendra Singh, S.
dc.contributor.authorChoo, Z.
dc.contributor.authorWang, C.
dc.contributor.authorYuan, Y.
dc.contributor.authorZea Tan, T.
dc.contributor.authorArfuso, Frank
dc.contributor.authorYap, C.
dc.contributor.authorPongor, L.
dc.contributor.authorYang, H.
dc.contributor.authorLee, M.
dc.contributor.authorCher Goh, B.
dc.contributor.authorSethi, G.
dc.contributor.authorBenoukraf, T.
dc.contributor.authorTergaonkar, V.
dc.contributor.authorPrem Kumar, A.
dc.date.accessioned2017-03-15T22:24:03Z
dc.date.available2017-03-15T22:24:03Z
dc.date.created2017-03-08T06:39:37Z
dc.date.issued2017
dc.date.submitted2017-03-08
dc.identifier.citationCai, W. and Xiong Chen, Z. and Rane, G. and Satendra Singh, S. and Choo, Z. and Wang, C. and Yuan, Y. et al. 2017. Wanted DEAD/H or Alive: Helicases Winding Up in Cancers. Journal of the National Cancer Institute. 109 (6): Article djw278.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/50416
dc.identifier.doi10.1093/jnci/djw278
dc.description.abstract

Cancer is one of the most studied areas of human biology over the past century. Despite having attracted much attention, hype, and investments, the search to find a cure for cancer remains an uphill battle. Recent discoveries that challenged the central dogma of molecular biology not only further increase the complexity but also demonstrate how various types of noncoding RNAs such as microRNA and long noncoding RNA, as well as their related processes such as RNA editing, are important in regulating gene expression. Parallel to this aspect, an increasing number of reports have focused on a family of proteins known as DEAD/H-box helicases involved in RNA metabolism, regulation of long and short noncoding RNAs, and novel roles as "editing helicases" and their association with cancers. This review summarizes recent findings on the roles of RNA helicases in various cancers, which are broadly classified into adult solid tumors, childhood solid tumors, leukemia, and cancer stem cells. The potential small molecule inhibitors of helicases and their therapeutic value are also discussed. In addition, analyzing next-generation sequencing data obtained from public portals and reviewing existing literature, we provide new insights on the potential of DEAD/H-box helicases to act as pharmacological drug targets in cancers.

dc.publisherOxford University Press
dc.titleWanted DEAD/H or Alive: Helicases Winding Up in Cancers.
dc.typeJournal Article
dcterms.dateSubmitted2017-03-08
dcterms.source.volume109
dcterms.source.number6
dcterms.source.issn1460-2105
dcterms.source.titleJournal of the National Cancer Institute
curtin.digitool.pid250140
curtin.departmentSchool of Biomedical Sciences
curtin.identifier.elementsidELEMENTS-143572
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record