The three Rs along the TRAIL: Resistance, re-sensitization and reactive oxygen species (ROS)
Citation
Source Title
ISSN
School
Collection
Abstract
Ligation of the Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) death receptors has been associated with cancer specific apoptotic execution in a number of model systems. This has generated tremendous interest in the use of TRAIL as a potential therapeutic modality. However, recent evidence indicates that resistance to TRAIL might present with a therapeutic challenge. In this short report, we review the basic biology of TRAIL signalling in cancer cells, highlight the mechanisms underlying resistance to TRAIL and the ability of small molecule compounds to re-sensitize cells to TRAIL-mediated apoptosis. In particular, we provide evidence that intracellular reactive oxygen species could be critical in regulating the response of cancer cells to TRAIL. © 2012 Informa UK, Ltd.
Related items
Showing items related by title, author, creator and subject.
-
Dai, X.; Zhang, J.; Arfuso, Frank; Chinnathambi, A.; Zayed, M.; Alharbi, S.; Kumar, A.; Ahn, K.; Sethi, G. (2015)© 2015 by the Society for Experimental Biology and Medicine Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to selectively induce apoptotic cell death in various tumor cells by engaging its ...
-
Gobbi, G.; Di Marcantonio, D.; Micheloni, C.; Carubbi, C.; Galli, D.; Vaccarezza, Mauro; Bucci, G.; Vitale, M.; Mirandola, P. (2012)PKC isoenzymes play central roles in various cellular signalling pathways, participating in a variety of protein phosphorylation cascades that regulate/modulate cellular structure and gene expression. It has been firmly ...
-
Ballantyne, M.; Gudes, Ori; Pickering, C. (2014)Remnant urban forests are often popular sites for recreational activities such as hiking, biking and motorised recreation. This can result in the formation of extensive trail networks, fragmenting vegetation into patches ...