The anti-oxidant and pro-oxidant dichotomy of Bcl-2.
MetadataShow full item record
Across a wide spectrum of cellular redox status, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. Of note, there is emerging evidence that the anti-apoptotic protein, Bcl-2, in addition to its conventional activity of titrating the pro-apoptotic effects of proteins such as Bax and Bak at the mitochondria, also impacts cell fate decisions via modulating cellular redox metabolism. In this regard, both pro- and anti-oxidant effects of Bcl-2 overexpression have been described under different conditions and cellular contexts. In this short review, we attempt to analyze existing observations and present a probable explanation for the seemingly conflicting redox regulating activity of Bcl-2 from the standpoint of its pro-survival function. The consequential effect(s) of the dual redox functions of Bcl-2 are also discussed, particularly from the viewpoint of developing novel therapeutic strategies against cancers rendered refractory due to the aberrant expression of Bcl-2.
Showing items related by title, author, creator and subject.
Evans, Katy (2006)Redox processes affect many aspects of geological systems. It is therefore useful to distinguish between chemical processes that result in changes in the capacities of reservoirs to oxidize or reduce from those that do ...
Evans, Katy (2012)Elements that can occur in more than one valence state, such as Fe, C and S, play an important role in Earth's systems at all levels, and can drive planetary evolution as they cycle through the various geochemical reservoirs. ...
The electrocatalytic characterization and mechanism of carbon nanotubes with different numbers of walls for the VO<inf>2</inf><sup>+</sup>/VO<sup>2+</sup>redox coupleLv, Z.; Zhang, J.; Lv, Y.; Cheng, Y.; Jiang, San Ping; Xiang, Y.; Lu, S. (2018)Â© 2018 the Owner Societies. Carbon nanotubes (CNTs) have been applied as catalysts in the VO 2 + /VO 2+ redox, whereas the mechanism of CNTs for the redox reaction is still unclear. In this work, the mechanism of the VO ...