Breast cancer risk and the interaction between adolescent body size and weight gain in later life: A case-control study
MetadataShow full item record
Background: While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. Methods: We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women. Logistic regression adjusted for the matching factor age and further potential confounders was used. Results: Adolescent body leanness in postmenopausal women and excess adult weight gain in all study participants were associated with an increased breast cancer risk with an odds ratio [95% confidence interval] of 1.29 [1.08,1.54] and 1.31 [1.09,1.59], respectively. Interaction analyses restricted to postmenopausal women revealed an increased risk of breast cancer in those who were lean during adolescence and gained excess weight during adulthood (odds ratio [95% confidence interval]: 1.52 [1.19,1.95]) but not in women who were lean during adolescence and did not gain excess weight during adulthood (1.20 [0.97,1.48]) and not in women who were not lean during adolescence and but gained excess weight during adulthood (1.10 [0.95,1.27]) compared to postmenopausal women who were neither lean during adolescence nor gained excess weight. Conclusion: In postmenopausal women adolescent leanness was only associated with increased breast cancer risk when excess weight was gained during adulthood.
Showing items related by title, author, creator and subject.
Inoue, Madoka (2012)This thesis examines infant feeding practices, including knowledge and attitudes towards breastfeeding, factors that influence the duration of breastfeeding, and breastfeeding outcomes in relation to postpartum women’s ...
Breast size, thoracic kyphosis & thoracic spine pain - association & relevance of bra fitting in post-menopausal women: A correlational study.Spencer, L.; Briffa, Kathy (2013)Background: Menopause would seem to exist as a period of accelerated changes for women and their upper torso mechanics. Whether these anthropometric changes reflect changes in pain states remains unclear. Plausible ...
Physical activity, obesity, weight change, and risk of atrial fibrillation the atherosclerosis risk in communities studyHuxley, Rachel; Misialek, J.; Agarwal, S.; Loehr, L.; Soliman, E.; Chen, L.; Alonso, A. (2014)© 2014 American Heart Association, Inc. Background-Physical activity (PA) has previously been suggested to attenuate the risk of atrial fibrillation (AF) conferred by excess body weight and weight gain. We prospectively ...