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    Mitochondria: Redox metabolism and dysfunction

    Access Status
    Open access via publisher
    Authors
    Kang, J.
    Pervaiz, Shazib
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Kang, J. and Pervaiz, S. 2012. Mitochondria: Redox metabolism and dysfunction. Biochemistry Research International.
    Source Title
    Biochemistry Research International
    DOI
    10.1155/2012/896751
    ISSN
    2090-2247
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51151
    Collection
    • Curtin Research Publications
    Abstract

    Mitochondria are the main intracellular location for fuel generation; however, they are not just power plants but involved in a range of other intracellular functions including regulation of redox homeostasis and cell fate. Dysfunction of mitochondria will result in oxidative stress which is one of the underlying causal factors for a variety of diseases including neurodegenerative diseases, diabetes, cardiovascular diseases, and cancer. In this paper, generation of reactive oxygen/nitrogen species (ROS/RNS) in the mitochondria, redox regulatory roles of certain mitochondrial proteins, and the impact on cell fate will be discussed. The current state of our understanding in mitochondrial dysfunction in pathological states and how we could target them for therapeutic purpose will also be briefly reviewed. © Copyright 2012 Jia Kang and Shazib Pervaiz.

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