Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator

    Access Status
    Fulltext not available
    Authors
    Chong, S.
    Low, I.
    Pervaiz, Shazib
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Chong, S. and Low, I. and Pervaiz, S. 2014. Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator. Mitochondrion. 19 (pt. A): pp. 39-48.
    Source Title
    Mitochondrion
    DOI
    10.1016/j.mito.2014.06.002
    ISSN
    1567-7249
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51171
    Collection
    • Curtin Research Publications
    Abstract

    Mitochondria are the major intracellular source of reactive oxygen species (ROS). While excessive mitochondrial ROS (mitoROS) production induces cell injury and death, there is accumulating evidence that non-toxic low levels of mitoROS could serve as important signaling molecules. Therefore, maintenance of mitoROS at physiological levels is crucial for cell homeostasis as well as for survival and proliferation. This review describes the various mechanisms that keep mitoROS in check, with particular focus on the role of the onco-protein Bcl-2 in redox regulation. In addition to its canonical anti-apoptotic activity, Bcl-2 has been implicated in mitoROS regulation by its effect on mitochondrial complex IV activity, facilitating the mitochondrial incorporation of GSH and interaction with the small GTPase-Rac1 at the mitochondria. We also discuss some of the plausible mechanism(s) which allows Bcl-2 to sense and respond to the fluctuations in mitoROS.

    Related items

    Showing items related by title, author, creator and subject.

    • Changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo are limited by irradiation at 670 nm
      Cummins, N.; Bartlett, C.; Archer, M.; Bartlett, E.; Hemmi, J.; Harvey, A.; Dunlop, S.; Fitzgerald, Melinda (2013)
      Background: Traumatic injury to the central nervous system results in damage to tissue beyond the primary injury, termed secondary degeneration. Key events thought to be associated with secondary degeneration involve ...
    • Reactive oxygen species, mitochondria, and endothelial cell death during in vitro simulated dives
      Wang, Q.; Guerrero, F.; Mazur, A.; Lambrechts, K.; Buzzacott, Peter; Belhomme, M.; Theron, M. (2015)
      © 2014 by the American College of Sports Medicine. Purpose Excessive reactive oxygen species (ROS) is considered a consequence of hyperoxia and a major contributor to diving-derived vascular endothelial damage and ...
    • Cardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis
      Lee, R.G.; Gao, J.; Siira, S.J.; Shearwood, A.M.; Ermer, J.A.; Hofferek, V.; Mathews, J.C.; Zheng, M.; Reid, G.E.; Rackham, Oliver ; Filipovska, Aleksandra (2020)
      The mitochondrial inner membrane contains a unique phospholipid known as cardiolipin (CL), which stabilises the protein complexes embedded in the membrane and supports its overall structure. Recent evidence indicates that ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.