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    A functionally conserved Zn2 Cys6 binuclear cluster transcription factor class regulates necrotrophic effector gene expression and host-specific virulence of two major Pleosporales fungal pathogens of wheat.

    Access Status
    Open access via publisher
    Authors
    Rybak, K.
    See, Pao Theen
    Phan, Huyen Phan
    Syme, Robert
    Moffat, Caroline
    Oliver, Richard
    Tan, Kar-Chun
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Rybak, K. and See, P.T. and Phan, H.P. and Syme, R. and Moffat, C. and Oliver, R. and Tan, K. 2017. A functionally conserved Zn2 Cys6 binuclear cluster transcription factor class regulates necrotrophic effector gene expression and host-specific virulence of two major Pleosporales fungal pathogens of wheat.. Molecular Plant Pathology. -.
    Source Title
    Molecular Plant Pathology
    DOI
    10.1111/mpp.12511
    ISSN
    1364-3703
    School
    Centre for Crop Disease Management
    URI
    http://hdl.handle.net/20.500.11937/51201
    Collection
    • Curtin Research Publications
    Abstract

    The fungus Parastagonospora nodorum is the causal agent of Septoria nodorum blotch of wheat (Triticum aestivum). The interaction is mediated by multiple fungal necrotrophic effector-dominant host sensitivity gene interactions. The three best-characterized effector-sensitivity gene systems are SnToxA-Tsn1, SnTox1-Snn1 and SnTox3-Snn3. These effector genes are highly expressed during early infection, but expression decreases as the infection progresses to tissue necrosis and sporulation. However, the mechanism of regulation is unknown. We have identified and functionally characterized a gene, referred to as PnPf2, which encodes a putative zinc finger transcription factor. PnPf2 deletion resulted in the down-regulation of SnToxA and SnTox3 expression. Virulence on Tsn1 and Snn3 wheat cultivars was strongly reduced. The SnTox1-Snn1 interaction remained unaffected. Furthermore, we have also identified and deleted an orthologous PtrPf2 from the tan spot fungus Pyrenophora tritici-repentis which possesses a near-identical ToxA that was acquired from P. nodorum via horizontal gene transfer. PtrPf2 deletion also resulted in the down-regulation of PtrToxA expression and a near-complete loss of virulence on Tsn1 wheat. We have demonstrated, for the first time, evidence for a functionally conserved signalling component that plays a role in the regulation of a common/horizontally transferred effector found in two major fungal pathogens of wheat.

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