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    Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence

    Access Status
    Fulltext not available
    Authors
    Shanmugam, M.
    Dai, X.
    Kumar, Alan Prem
    Tan, B.
    Sethi, G.
    Bishayee, A.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Shanmugam, M. and Dai, X. and Kumar, A.P. and Tan, B. and Sethi, G. and Bishayee, A. 2014. Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence. Cancer Letters. 346 (2): pp. 206-216.
    Source Title
    Cancer Letters
    DOI
    10.1016/j.canlet.2014.01.016
    ISSN
    0304-3835
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51203
    Collection
    • Curtin Research Publications
    Abstract

    Oleanolic acid (OA, 3ß-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-?B, AKT, signal transducer and activator of transcription 3, mammalian target of rapamycin, caspases, intercellular adhesion molecule 1, vascular endothelial growth factor, and poly (ADP-ribose) polymerase in a variety of tumor cells. Importantly, synthetic derivative of OA, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), and its C-28 methyl ester (CDDO-Me) and C28 imidazole (CDDO-Im) have demonstrated potent antiangiogenic and antitumor activities in rodent cancer models. These agents are presently under evaluation in phase I studies in cancer patients. This review summarizes the diverse molecular targets of OA and its derivatives and also provides clear evidence on their promising potential in preclinical and clinical situations.

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