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    ß-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men

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    Fulltext not available
    Authors
    Holmes, S.
    Esterlis, I.
    Mazure, C.
    Lim, Y.
    Ames, D.
    Rainey-Smith, S.
    Martins, R.
    Salvado, O.
    Dore, V.
    Villemagne, V.
    Rowe, C.
    Laws, Simon
    Masters, C.
    Maruff, P.
    Pietrzak, R.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Holmes, S. and Esterlis, I. and Mazure, C. and Lim, Y. and Ames, D. and Rainey-Smith, S. and Martins, R. et al. 2016. ß-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal of Geriatric Psychiatry. 24 (12): pp. 1191-1195.
    Source Title
    American Journal of Geriatric Psychiatry
    DOI
    10.1016/j.jagp.2016.08.007
    ISSN
    1064-7481
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51254
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 American Association for Geriatric PsychiatryObjective To examine how ß-amyloid (Aß), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aß, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aß+ older adults, APOE e4 carriage was associated with greater severity of anxiety symptoms (d?=?0.55); and in the full sample, APOE e4 carriage was linked to greater severity of depressive (d?=?0.26) and anxiety (d?=?0.21) symptoms. Among Aß+ women, e4 carriers reported greater anxiety symptoms than non-e4 carriers (d?=?0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d?=?0.29). Conclusion Sex moderated the relationship between Aß, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.

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