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    NHE-1: A promising target for novel anti-cancer therapeutics

    Access Status
    Fulltext not available
    Authors
    Loo, S.
    Chang, M.
    Chua, C.
    Kumar, A.
    Pervaiz, Shazib
    Clement, M.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Loo, S. and Chang, M. and Chua, C. and Kumar, A. and Pervaiz, S. and Clement, M. 2012. NHE-1: A promising target for novel anti-cancer therapeutics. Current Pharmaceutical Design. 18 (10): pp. 1372-1382.
    Source Title
    Current Pharmaceutical Design
    ISSN
    1381-6128
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51282
    Collection
    • Curtin Research Publications
    Abstract

    Among the many factors involved in the maintenance of homeostatic growth is the tight regulation of cellular pH. Intracellular pH of normal cells is maintained within a physiological range thanks to the activity of a number of pH regulators that respond to the acid-base shifts associated with normal cellular metabolic processes. Interestingly, there is a preponderance of evidence that dysregulation of intracellular pH is associated with processes that favor cell transformation such as cell cycle progression, enhanced proliferation, insensitivity to growth inhibitory stimuli, resistance to apoptosis, genomic instability and angiogenesis. Among the strategies employed by the cells to regulate intracellular pH, the Na+/H+ exchanger 1 (NHE1) protein from the Na+/H+ exchanger (NHE) family has been directly associated with cellular transformation, invasion and metastasis. These observations have heightened the interest in NHE1 as a promising novel drug target for more effective and selective anti-cancer therapeutics. Here we present a review of the basic biology of this remarkable protein and present evidence to support targeting NHE1 as a potential anti-cancer strategy. © 2012 Bentham Science Publishers.

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