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dc.contributor.authorRazak, N.
dc.contributor.authorElaskalani, O.
dc.contributor.authorMetharom, Pat
dc.date.accessioned2017-03-24T11:53:45Z
dc.date.available2017-03-24T11:53:45Z
dc.date.created2017-03-23T06:59:48Z
dc.date.issued2017
dc.identifier.citationRazak, N. and Elaskalani, O. and Metharom, P. 2017. Pancreatic cancer-induced neutrophil extracellular traps: A potential contributor to cancer-associated thrombosis. International Journal of Molecular Science. 18 (3): 487.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/51506
dc.identifier.doi10.3390/ijms18030487
dc.description.abstract

Pancreatic cancer (PaCa) is a highly metastatic cancer, and patients are at high risk of developing venous thromboembolism (VTE). Neutrophil extracellular traps (NETs) have been associated with cancer metastasis and cancer-associated thrombosis, but the ability of cancer to stimulate NET release is not known. The release of NETs has been shown to be a slow process and requires reactive oxygen species (ROS) production. Studies suggest that activated platelets are important mediators in the release. Here, we show that PaCa cells can stimulate the rapid release of NETs, independently of ROS production. We further assessed the role of platelets in PaCa-induced NETs and observed a trend of increased the NET release by PaCa-primed platelets. Additionally, NETs promoted thrombus formation under venous shear stress ex vivo. Taken together, our results suggest that PaCa-induced NETs can contribute to the high risk of venous thromboembolism development in PaCa patients, and reveal NETs as a potential therapeutic target.

dc.publisherMDPI AG
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titlePancreatic cancer-induced neutrophil extracellular traps: A potential contributor to cancer-associated thrombosis
dc.typeJournal Article
dcterms.source.volume18
dcterms.source.number3
dcterms.source.issn1661-6596
dcterms.source.titleInternational Journal of Molecular Science
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences


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