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    Vitamin D status and calcium intake in systemic inflammation, insulin resistance and the metabolic syndrome: An update on current evidence

    Access Status
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    Authors
    Soares, Mario
    Pannu, Poonam
    Calton, Emily
    Reid, Christopher
    Hills, A.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Soares, M. and Pannu, P. and Calton, E. and Reid, C. and Hills, A. 2017. Vitamin D status and calcium intake in systemic inflammation, insulin resistance and the metabolic syndrome: An update on current evidence. Trends in Food Science and Technology. 62: pp. 79-90.
    Source Title
    Trends in Food Science and Technology
    DOI
    10.1016/j.tifs.2017.01.009
    ISSN
    0924-2244
    School
    Department of Health Policy and Management
    URI
    http://hdl.handle.net/20.500.11937/51565
    Collection
    • Curtin Research Publications
    Abstract

    Background: Insufficient vitamin D status and inadequate intakes of calcium are a global concern and appear to be inversely linked to the global explosion in prevalence of the metabolic syndrome (MetS). Scope and approach: This review provides an update of the current evidence on causal linkages between these nutrients and MetS. We adopted a simplified model that explored the effects of vitamin D and calcium on systemic inflammation and insulin resistance (IR), as initial derangements in the progression to MetS. We selected systematic reviews (SR) and meta-analyses (MA) of randomized controlled trials (RCTs) or large scale observational studies to better understand the evidence base in the area. Key findings and conclusions: Observational data provided the best evidence for an inverse association between vitamin D status and presence of MetS. There was no convincing evidence from RCTs, except when participants with impaired glucose tolerance were studied. The influence of dietary calcium on systemic inflammation, IR and MetS has been inadequately studied to allow a firm conclusion. However, cellular and molecular evidence support a role for intra-cellular calcium in related disease states. Future long-term RCTs in adequately sampled participant groups are needed. Central to uncovering such extra-skeletal effects is the endpoint of interest, the selection of the study population, the potential of prior genotyping, consensus on ‘optimal’ vitamin D status, and the duration required of future trials. The concomitant study of mechanistic pathways in such trials could uncover potential targets for functional food development and drug therapy.

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