A brief review of drug discovery research for Human African Trypanosomiasis
MetadataShow full item record
Human African Trypanosomiasis (HAT), a neglected disease endemic in Sub-Saharan Africa, is usually fatal if left untreated. It is caused by the parasite Trypanosoma brucei, and is spread by the tsetse fly. The drugs currently available to treat HAT are few, and limited in efficacy. Furthermore, resistance towards these drugs is beginning to grow. In the last 25 years only one advance has been made into HAT treatment and consequently, there is an increasing need for new drugs to be sought that are able to effectively treat this disease. This review provides a brief overview of drug discovery research for HAT, focusing on research published in the last four years, identifying new molecules with the potential to be developed into anti-HAT agents. The methods of drug discovery have been grouped into three key areas; new molecules inspired by known antitrypanosomal agents, target-based screening, and phenotypic screening.
Showing items related by title, author, creator and subject.
Exploring the micro-politics of normalised drug use in the social lives of a group of young 'party drug' users in Melbourne, AustraliaPennay, Amy (2012)Young people today live in what some scholars and commentators have defined as a 'post-modern' era, characterised by globalisation, the internet, mass media, production and consumption. Post-modernity has seen a change ...
An ethnographic study of recreational drug use and identity management among a network of electronic dance music enthusiasts in Perth, Western AustraliaGreen, Rachael Renee (2012)This thesis explores the social contexts and cultural significance of amphetamine-type stimulant (ATS) and alcohol use among a social network of young adults in Perth, Western Australia. The study is positioned by the ...
Dwyer, Robyn (2009)This thesis is concerned with the exchange of heroin in localised, street-based marketplaces. Commercial exchange of heroin in such sites has been a characteristic of the Australian heroin scene since the early 1990s. ...