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    Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model

    Alhashmi I 2012.pdf (11.02Mb)
    Access Status
    Open access
    Authors
    Alhashmi, Ibrahim
    Date
    2012
    Supervisor
    Assoc. Prof. Trilochan Mukkur
    Prof. John Wetherall
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/51705
    Collection
    • Curtin Theses
    Abstract

    This thesis embodies research that has demonstrated that there is strong case for further development of novel live attenuated metabolite deficient B pertussis vaccine such that it is non-toxic because it polarises the immune response of DTaP-vaccinated mice from Th2 to Th1 following booster vaccination with the live attenuated vaccine thus offering the chance of long term protection against whooping cough and disrupting the transmission from adolescents and adults to infants.

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