Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model
MetadataShow full item record
This thesis embodies research that has demonstrated that there is strong case for further development of novel live attenuated metabolite deficient B pertussis vaccine such that it is non-toxic because it polarises the immune response of DTaP-vaccinated mice from Th2 to Th1 following booster vaccination with the live attenuated vaccine thus offering the chance of long term protection against whooping cough and disrupting the transmission from adolescents and adults to infants.
Showing items related by title, author, creator and subject.
The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young childrenBlyth, C.; Richmond, P.; Jacoby, P.; Thornton, P.; Regan, Annette; Robins, C.; Kelly, H.; Smith, D.; Effler, P. (2014)Introduction: Parental attitudes towards vaccination significantly influence vaccine uptake. The A(H1N1)pdm09 influenza pandemic was followed in 2010 by an unprecedented increase in febrile reactions in children receiving ...
Enkel, S.; Attwell, K.; Snelling, Thomas; Christian, H. (2017)Objective: Some parents are hesitant about vaccines and yet still vaccinate their children. Vaccine behaviours are not fixed and parents who are concerned but nonetheless adherent to standard schedules could switch to an ...
Mass Vaccination with a New, Less Expensive Oral Cholera Vaccine Using Public Health Infrastructure in India: The Odisha ModelKar, S.; Sah, B.; Patnaik, B.; Kim, Y.; Kerketta, A.; Shin, S.; Rath, S.; Ali, Mohammed; Mogasale, V.; Khuntia, H.; Bhattachan, A.; You, Y.; Puri, M.; Lopez, A.; Maskery, B.; Nair, G.; Clemens, J.; Wierzba, T. (2014)Introduction: The substantial morbidity and mortality associated with recent cholera outbreaks in Haiti and Zimbabwe, as well as with cholera endemicity in countries throughout Asia and Africa, make a compelling case for ...