Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model
| dc.contributor.author | Alhashmi, Ibrahim | |
| dc.contributor.supervisor | Assoc. Prof. Trilochan Mukkur | en_US |
| dc.contributor.supervisor | Prof. John Wetherall | en_US |
| dc.date.accessioned | 2017-04-11T03:47:29Z | |
| dc.date.available | 2017-04-11T03:47:29Z | |
| dc.date.issued | 2012 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/51705 | |
| dc.description.abstract |
This thesis embodies research that has demonstrated that there is strong case for further development of novel live attenuated metabolite deficient B pertussis vaccine such that it is non-toxic because it polarises the immune response of DTaP-vaccinated mice from Th2 to Th1 following booster vaccination with the live attenuated vaccine thus offering the chance of long term protection against whooping cough and disrupting the transmission from adolescents and adults to infants. | en_US |
| dc.publisher | Curtin University | en_US |
| dc.title | Live Metabolite-Deficient Bordetella pertussis: Determination of Suitability for use as a Vaccine in Humans using the Pertussis Mouse Model | en_US |
| dc.type | Thesis | en_US |
| dcterms.educationLevel | PhD | en_US |
| curtin.department | School of Biomedical Sciences | en_US |
| curtin.accessStatus | Open access | en_US |
| curtin.faculty | Health Sciences | en_US |