Preparation and in vitro release of zein microparticles loaded with prednisolone for oral delivery
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Zein has been proposed as a polymer for targeted-drug delivery via the oral route. Zein microparticles were loaded with prednisolone and evaluated as an oral delivery system. Microparticles were formulated using phase separation. Starting quantities of zein and prednisolone, along with the agitation method and temperature were found to significantly impact drug loading and loading efficiency. Vortex mixing produced the highest drug loading and loading efficiency. Drug release was measured in simulated conditions of the stomach and small intestine using the microparticles made with the method that best improved drug loading. In simulated stomach and small intestine conditions, prednisolone release reached almost 70% over 3 and 4 h, respectively. While a clinically relevant dose may be delivered using c. 100 mg of zein microparticles, prednisolone release from the microparticles indicates that they may not be suited as a controlled- or targeted-delivery system.
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Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin ProteinLau, E.; Johnson, Stuart; Stanley, R.; Mikkelsen, D.; Fang, Zhongxiang; Halley, P.; Steadman, K. (2015)Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an ...
Lau, E.; Giddings, S.; Mohammed, S.; Dubois, Paul; Johnson, Stuart; Stanley, R.; Halley, P.; Steadman, K. (2013)Zein was investigated for use as an oral-drug delivery system by loading prednisolone into zein microparticles using coacervation. To investigate the adaptability of this method to other drugs, zein microparticles were ...
Lau, E.; Johnson, Stuart; Stanley, R.; Mereddy, R.; Mikkelsen, D.; Halley, P.; Steadman, K. (2015)Kafirin, a protein extracted from sorghum grain, has been formulated into microparticles and proposed for use as a delivery system owing to the resistance of kafirin to upper gastrointestinal digestion. However, extracting ...