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dc.contributor.authorPohl, S.
dc.contributor.authorBrook, N.
dc.contributor.authorAgostino, Mark
dc.contributor.authorArfuso, Frank
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorDharmarajan, Arunasalam
dc.identifier.citationPohl, S. and Brook, N. and Agostino, M. and Arfuso, F. and Kumar, A.P. and Dharmarajan, A. 2017. Wnt signaling in triple-negative breast cancer. Oncogenesis. 6: e310.

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.

dc.titleWnt signaling in triple-negative breast cancer
dc.typeJournal Article
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access

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