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    Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation

    Access Status
    Fulltext not available
    Authors
    Ibsen, C.
    Gebauer, Denis
    Birkedal, H.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Ibsen, C. and Gebauer, D. and Birkedal, H. 2016. Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation. ZzChemical Materials. 28 (23): pp. 8550-8555.
    Source Title
    ZzChemical Materials
    DOI
    10.1021/acs.chemmater.6b01088
    ISSN
    0897-4756
    School
    Department of Chemistry
    URI
    http://hdl.handle.net/20.500.11937/52203
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 American Chemical Society.Osteopontin, which is a phosphoprotein with strong ties to in vivo bone mineralization, is shown to change the precipitation pathway of calcium phosphate. We show that the presence of the phosphoprotein, even in minute concentrations, can stabilize an otherwise oversaturated mixture against precipitation. At moderate concentrations, we find that the protein introduces a new intermediate state into the reaction pathway leading to apatite formation. This new intermediate was found to share many characteristics of a coacervate or polymer-induced liquid-like precursor (PILP) phase. Our results show that these types of complex phases should be considered when discussing the mechanisms of bone mineralization on a subcellular level.

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